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• W1981427767 abstract "Vascular cell adhesion molecule 1 (VCAM-1) is involved in the recruitment of leukocytes to inflammatory sites. In this study we present the first functional knockdown of VCAM-1 using an ER retained antibody construct. We generated a knockdown construct encoding the VCAM-1 specific single chain variable fragment scFv6C7.1 fused to the C-terminal ER retention sequence KDEL. HEK-293:VCAM-YFP cells stably expressing a VCAM-YFP fusion protein were transiently transfected with the knockdown construct and showed down-regulation of surface VCAM-1. Knockdown efficiency of the system is time-dependent due to used transient transfection of the intrabody construct. Furthermore, intrabody mediated knockdown of HEK-293:VCAM-YFP cells also impaired cell–cell interaction with Jurkat cells that are endogenously expressing VLA-4, the physiological partner of VCAM-1. Posttranslational knockdown with ER retained antibodies seems to be a promising technique, as shown here for VCAM-1." @default.
• W1981427767 created "2016-06-24" @default.
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• W1981427767 date "2009-02-01" @default.
• W1981427767 modified "2023-09-27" @default.
• W1981427767 title "Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies" @default.
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• W1981427767 doi "https://doi.org/10.1016/j.jim.2008.10.012" @default.
• W1981427767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19038261" @default.
• W1981427767 hasPublicationYear "2009" @default.
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