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- W1981444304 abstract "Transcapillary escape rates of albumin and IgG (fractions of intravascular mass of albumin and IgG that pass to the extravascular space per unit time) were determined simultaneously from the initial disappearance of intravenously injected 131I human albumin and 125I human IgG in seven untreated subjects suffering from essential hypertension. The average mean arterial blood pressure of these subjects was 193/119 mmHg; four subjects had grade I-III funduscopic changes. Transcapillary escape rates of albumin (TERalb) and IgG (TERIgG) were found significantly increased in the hypertensive subjects, average 7.8±0.9 (SD) and 4.7±1.0 (SD) %/h, respectively, compared with normal values of mean 5.2±1.0 (SD) and 3.0±0.7 (SD) %/h, respectively (P<0.01). There was a statistically significant positive correlation between the mean arterial blood pressure and TER of albumin and of IgG (P<0.001). The TER1gG/TERalb ratio was about the same in the hypertensives and the normals. Confirming a previous observation, we found an increase in the daily urinary albumin excretion rate from a normal average of 9.1 (range, 2.4-20.4)mg/24 h to 96 (range, 5.6-565) mg/24 h, P<005. The present findings can best be explained by increased filtration through normal pores between the endothelial cells in the microvascula-ture, due to the high arterial blood pressure." @default.
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- W1981444304 date "1977-01-01" @default.
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- W1981444304 title "Increased transcapillary escape rate of albumin and IgG in essential hypertension" @default.
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- W1981444304 doi "https://doi.org/10.3109/00365517709091486" @default.
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