FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981445835> ?p ?o ?g. }

• W1981445835 endingPage "165" @default.
• W1981445835 startingPage "157" @default.
• W1981445835 abstract "Combined serotonin (5-HT)(2A) and dopamine (DA) D(2) blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC). We provide additional support for this hypothesis by examining the effect of the selective 5-HT(2A) antagonist M100907 plus haloperidol, a potent D(2) antagonist APD, on DA release in the mPFC and nucleus accumbens (NAC). Haloperidol (0.01-1.0 mg/kg) produced an inverted U-shaped increase in DA release in the mPFC, with a significant increase only at 0.1 mg/kg. Haloperidol (0.1 and 1.0 mg/kg) significantly increased DA release in the NAC. M100907 (0.1 mg/kg) by itself had no effect on DA release in either region. This dose of M100907 potentiated the ability of low (0.01-0.1 mg/kg), but not high dose (0.3-1.0 mg/kg) haloperidol to increase mPFC DA release, whereas it abolished the effect of both 0.1 and 1.0 mg/kg haloperidol on NAC DA release. These results suggest that the relatively higher ratio of 5-HT(2A) to D(2) antagonism may contribute to the potentiation of haloperidol-induced mPFC DA release, whereas 5-HT(2A) antagonism can diminish haloperidol-induced NAC DA release, even when combined with extensive D(2) antagonism, which may not be synergistic with 5-HT(2A) antagonism in the mPFC." @default.
• W1981445835 created "2016-06-24" @default.
• W1981445835 creator A5004821881 @default.
• W1981445835 creator A5006759821 @default.
• W1981445835 creator A5060728653 @default.
• W1981445835 date "2002-08-01" @default.
• W1981445835 modified "2023-10-13" @default.
• W1981445835 title "5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner" @default.
• W1981445835 cites W1964176367 @default.
• W1981445835 cites W1966515892 @default.
• W1981445835 cites W1966628725 @default.
• W1981445835 cites W1967092126 @default.
• W1981445835 cites W1968085246 @default.
• W1981445835 cites W1970319148 @default.
• W1981445835 cites W1972836962 @default.
• W1981445835 cites W1978594836 @default.
• W1981445835 cites W1979700184 @default.
• W1981445835 cites W1983956132 @default.
• W1981445835 cites W1991724312 @default.
• W1981445835 cites W1993622808 @default.
• W1981445835 cites W1995807677 @default.
• W1981445835 cites W2009915820 @default.
• W1981445835 cites W2014113450 @default.
• W1981445835 cites W2020146737 @default.
• W1981445835 cites W2020741748 @default.
• W1981445835 cites W2021604694 @default.
• W1981445835 cites W2029267570 @default.
• W1981445835 cites W2031472570 @default.
• W1981445835 cites W2032517670 @default.
• W1981445835 cites W2033686632 @default.
• W1981445835 cites W2034785102 @default.
• W1981445835 cites W2034861437 @default.
• W1981445835 cites W2035900998 @default.
• W1981445835 cites W2039534965 @default.
• W1981445835 cites W2044104071 @default.
• W1981445835 cites W2048024033 @default.
• W1981445835 cites W2049405310 @default.
• W1981445835 cites W2050378039 @default.
• W1981445835 cites W2059912456 @default.
• W1981445835 cites W2060967710 @default.
• W1981445835 cites W2068026066 @default.
• W1981445835 cites W2071844775 @default.
• W1981445835 cites W2072069319 @default.
• W1981445835 cites W2075901584 @default.
• W1981445835 cites W2083109085 @default.
• W1981445835 cites W2083252023 @default.
• W1981445835 cites W2084556472 @default.
• W1981445835 cites W2089763555 @default.
• W1981445835 cites W2090404564 @default.
• W1981445835 cites W2092820864 @default.
• W1981445835 cites W2099576957 @default.
• W1981445835 cites W2104465880 @default.
• W1981445835 cites W2106352416 @default.
• W1981445835 cites W2139704528 @default.
• W1981445835 cites W2143080892 @default.
• W1981445835 cites W2151331628 @default.
• W1981445835 cites W2161570416 @default.
• W1981445835 cites W2162836351 @default.
• W1981445835 cites W2163015549 @default.
• W1981445835 cites W2165194242 @default.
• W1981445835 cites W2401206973 @default.
• W1981445835 doi "https://doi.org/10.1016/s0006-8993(02)02620-3" @default.
• W1981445835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12176156" @default.
• W1981445835 hasPublicationYear "2002" @default.
• W1981445835 type Work @default.
• W1981445835 sameAs 1981445835 @default.
• W1981445835 citedByCount "128" @default.
• W1981445835 countsByYear W19814458352012 @default.
• W1981445835 countsByYear W19814458352013 @default.
• W1981445835 countsByYear W19814458352014 @default.
• W1981445835 countsByYear W19814458352015 @default.
• W1981445835 countsByYear W19814458352016 @default.
• W1981445835 countsByYear W19814458352017 @default.
• W1981445835 countsByYear W19814458352018 @default.
• W1981445835 countsByYear W19814458352019 @default.
• W1981445835 countsByYear W19814458352021 @default.
• W1981445835 crossrefType "journal-article" @default.
• W1981445835 hasAuthorship W1981445835A5004821881 @default.
• W1981445835 hasAuthorship W1981445835A5006759821 @default.
• W1981445835 hasAuthorship W1981445835A5060728653 @default.
• W1981445835 hasConcept C134018914 @default.
• W1981445835 hasConcept C15744967 @default.
• W1981445835 hasConcept C169760540 @default.
• W1981445835 hasConcept C169900460 @default.
• W1981445835 hasConcept C170493617 @default.
• W1981445835 hasConcept C185592680 @default.
• W1981445835 hasConcept C2776552330 @default.
• W1981445835 hasConcept C2776885963 @default.
• W1981445835 hasConcept C2777383412 @default.
• W1981445835 hasConcept C2780948584 @default.
• W1981445835 hasConcept C2781195155 @default.
• W1981445835 hasConcept C2781353949 @default.
• W1981445835 hasConcept C44208683 @default.
• W1981445835 hasConcept C513476851 @default.
• W1981445835 hasConcept C55493867 @default.
• W1981445835 hasConcept C71924100 @default.
• W1981445835 hasConcept C98274493 @default.
• W1981445835 hasConceptScore W1981445835C134018914 @default.

• next