Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981450224> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1981450224 endingPage "74a" @default.
- W1981450224 startingPage "74a" @default.
- W1981450224 abstract "Although prokaryotes lack the machinery utilized by eukaryotes to achieve well organized chromosome segregation, all cells must faithfully segregate their chromosomes in every cell division cycle. In many bacteria, this process is dependent upon a partitioning locus composed of an ATPase called ParA, a DNA binding protein called ParB, and centromere-like binding sites (parS) that are present adjacent to the origin of replication. ParB binds the parS, sites and the ParA ATPase acts on the ParB-parS complex to facilitate segregation of replicated origins toward opposite cell poles. In Bacillus subtilis, the ParA protein is called Soj and the ParB protein is referred to as Spo0J. There are eight parS sites surrounding the origin of replication of the B. subtilis chromosome. Spo0J can bind to these sites and spread along the DNA up to 15 kilobases, forming a nucleoprotein complex. The Spo0J-parS complexes are not only a substrate for Soj/ParB, but they also serve to recruit the highly conserved structural maintenance of chromosomes (SMC) complex to the origin. The SMC condensin complex appears to function in both organizing the origin region and facilitating chromosome segregation. To investigate how Spo0J spreads along the DNA and ultimately how this complex recruits SMC, we have employed single molecule fluorescence imaging to directly observe the formation of the nucleoprotein complex of purified B. subtilis Spo0J and lambda DNA. We characterize the physical properties of this nucleoprotein complex and the kinetics of its formation." @default.
- W1981450224 created "2016-06-24" @default.
- W1981450224 creator A5055700278 @default.
- W1981450224 creator A5065212721 @default.
- W1981450224 creator A5075591359 @default.
- W1981450224 date "2010-01-01" @default.
- W1981450224 modified "2023-09-30" @default.
- W1981450224 title "Nucleoprotein Complex Formation By Bacillus Subtilis Spo0J/ParB" @default.
- W1981450224 doi "https://doi.org/10.1016/j.bpj.2009.12.418" @default.
- W1981450224 hasPublicationYear "2010" @default.
- W1981450224 type Work @default.
- W1981450224 sameAs 1981450224 @default.
- W1981450224 citedByCount "0" @default.
- W1981450224 crossrefType "journal-article" @default.
- W1981450224 hasAuthorship W1981450224A5055700278 @default.
- W1981450224 hasAuthorship W1981450224A5065212721 @default.
- W1981450224 hasAuthorship W1981450224A5075591359 @default.
- W1981450224 hasBestOaLocation W19814502241 @default.
- W1981450224 hasConcept C104292427 @default.
- W1981450224 hasConcept C104317684 @default.
- W1981450224 hasConcept C151158763 @default.
- W1981450224 hasConcept C2777272437 @default.
- W1981450224 hasConcept C2778354886 @default.
- W1981450224 hasConcept C30481170 @default.
- W1981450224 hasConcept C523546767 @default.
- W1981450224 hasConcept C54355233 @default.
- W1981450224 hasConcept C552990157 @default.
- W1981450224 hasConcept C58337764 @default.
- W1981450224 hasConcept C60325843 @default.
- W1981450224 hasConcept C63491729 @default.
- W1981450224 hasConcept C73573662 @default.
- W1981450224 hasConcept C86803240 @default.
- W1981450224 hasConcept C95444343 @default.
- W1981450224 hasConcept C98086919 @default.
- W1981450224 hasConceptScore W1981450224C104292427 @default.
- W1981450224 hasConceptScore W1981450224C104317684 @default.
- W1981450224 hasConceptScore W1981450224C151158763 @default.
- W1981450224 hasConceptScore W1981450224C2777272437 @default.
- W1981450224 hasConceptScore W1981450224C2778354886 @default.
- W1981450224 hasConceptScore W1981450224C30481170 @default.
- W1981450224 hasConceptScore W1981450224C523546767 @default.
- W1981450224 hasConceptScore W1981450224C54355233 @default.
- W1981450224 hasConceptScore W1981450224C552990157 @default.
- W1981450224 hasConceptScore W1981450224C58337764 @default.
- W1981450224 hasConceptScore W1981450224C60325843 @default.
- W1981450224 hasConceptScore W1981450224C63491729 @default.
- W1981450224 hasConceptScore W1981450224C73573662 @default.
- W1981450224 hasConceptScore W1981450224C86803240 @default.
- W1981450224 hasConceptScore W1981450224C95444343 @default.
- W1981450224 hasConceptScore W1981450224C98086919 @default.
- W1981450224 hasIssue "3" @default.
- W1981450224 hasLocation W19814502241 @default.
- W1981450224 hasLocation W19814502242 @default.
- W1981450224 hasOpenAccess W1981450224 @default.
- W1981450224 hasPrimaryLocation W19814502241 @default.
- W1981450224 hasRelatedWork W1970203866 @default.
- W1981450224 hasRelatedWork W1972834791 @default.
- W1981450224 hasRelatedWork W1981450224 @default.
- W1981450224 hasRelatedWork W2024036287 @default.
- W1981450224 hasRelatedWork W2048946569 @default.
- W1981450224 hasRelatedWork W2119872883 @default.
- W1981450224 hasRelatedWork W2166215008 @default.
- W1981450224 hasRelatedWork W2909051999 @default.
- W1981450224 hasRelatedWork W3034359544 @default.
- W1981450224 hasRelatedWork W3099074853 @default.
- W1981450224 hasVolume "98" @default.
- W1981450224 isParatext "false" @default.
- W1981450224 isRetracted "false" @default.
- W1981450224 magId "1981450224" @default.
- W1981450224 workType "article" @default.