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• W1981456165 abstract "The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4′-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4′-trihydroxy-7,8,3′-trimethoxyflavone (7), 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3′,4′-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4′-trimethoxyflavone (10). The IC50 values of compounds 6–10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1 μM. Compounds 7 and 9 (IC50 2.4 μM and 3.0 μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7 mg/kg, 278.0 mg/kg, and 179.7 mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6–10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy." @default.
• W1981456165 created "2016-06-24" @default.
• W1981456165 creator A5035020235 @default.
• W1981456165 creator A5041689745 @default.
• W1981456165 date "2015-04-01" @default.
• W1981456165 modified "2023-10-18" @default.
• W1981456165 title "High antiallergic activity of 5,6,4′-trihydroxy-7,8,3′-trimethoxyflavone and 5,6-dihydroxy-7,8,3′,4′-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata)" @default.
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• W1981456165 doi "https://doi.org/10.1016/j.fitote.2015.02.003" @default.
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