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- W1981457844 abstract "A highly sensitive and selective Ag+ detection method was developed based on the Ag+-mediated formation of G-quadruplex–hemin DNAzymes. In this method, two unlabelled oligonucleotides with different lengths are used. In the absence of Ag+, the two oligonucleotides hybridize to each other to form an intermolecular duplex. The addition of Ag+ can disrupt the intermolecular duplex and promote a part of the sequence of the longer oligonucleotide to fold into an intramolecular duplex, in which cytosine–cytosine (C–C) mismatches are stabilized by C–Ag+–C base pairs. As a result, the G-rich sequence of the same oligonucleotide can fold into a G-quadruplex, which is able to bind hemin to form a catalytically active G-quadruplex–hemin DNAzyme. This can be reflected by an absorbance increase when monitored in the H2O2–ABTS (2,2′-azinobis(3-ethylbenzothiozoline)-6-sulfonic acid) reaction system by using UV-vis absorption spectroscopy. This ‘turn-on’ process allows the detection of aqueous Ag+ at concentrations as low as 20 nM using a simple colorimetric technique. Considering that Cysteine (Cys) is a strong binder of Ag+, the presence of Cys may disrupt the C–Ag+–C base pairs in the intramolecular duplex, resulting in the reformation of the intermolecular duplex and the decrease of the catalytic activity of the sensing system. Therefore, the Ag+-sensing system can be further developed as a Cys-sensing system. This method allows the detection of Cys with a detection limit of 25 nM. With the development of the studies on DNA–metal base pairs, this Ag+-sensing method can be easily extended to the analysis of other metal ions." @default.
- W1981457844 created "2016-06-24" @default.
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- W1981457844 date "2010-01-01" @default.
- W1981457844 modified "2023-10-17" @default.
- W1981457844 title "Quantitative detection of Ag+ and cysteine using G-quadruplex–hemin DNAzymes" @default.
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- W1981457844 doi "https://doi.org/10.1039/b925168e" @default.
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