FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981463456> ?p ?o ?g. }

• W1981463456 abstract "Aquaporin-4 (AQP4), the most abundant water channel in the brain, plays a central role in water homeostasis, neuronal activity, and migration of astrocytes in the central nervous system. Recent studies have demonstrated that AQP4 is a target of an autoantibody specifically detected in an autoimmune neurologic disease called neuromyelitis optica. Here we have generated a monoclonal antibody (MAb) against the C-terminal region of AQP4 using a baculovirus expressing mouse AQP4 as an immunogen. This antibody (clone E5206) recognized both human and mouse AQP4s in a denaturing condition and was able to precipitate AQP4 from cell lysates of CHO cells stably expressing AQP4. Western blot analysis using deletion mutants revealed that the epitope was located within a region between Asp(303) and Leu(320) in the C-terminal tail of AQP4. Although clone E5206 could not be used for immunostaining when cells or tissues were fixed with 4% paraformaldehyde or 10% formalin, it could be used when cells were fixed with 10% trichloroacetic acid and when a formalin-fixed tissue section was pretreated with antigen-retrieval reagents. This MAb can be a valuable tool for analysis of AQP4 in a variety of physiological and pathophysiological contexts, in human tissues and organs as well as in rodent models, both in vitro and in vivo." @default.
• W1981463456 created "2016-06-24" @default.
• W1981463456 creator A5006295807 @default.
• W1981463456 creator A5020185674 @default.
• W1981463456 creator A5020189095 @default.
• W1981463456 creator A5038995187 @default.
• W1981463456 creator A5043353316 @default.
• W1981463456 creator A5053916125 @default.
• W1981463456 creator A5059312106 @default.
• W1981463456 creator A5068037677 @default.
• W1981463456 creator A5071033580 @default.
• W1981463456 creator A5079094617 @default.
• W1981463456 date "2013-08-01" @default.
• W1981463456 modified "2023-10-02" @default.
• W1981463456 title "A Novel Monoclonal Antibody Against the C-Terminal Region of Aquaporin-4" @default.
• W1981463456 cites W1535419310 @default.
• W1981463456 cites W1536896113 @default.
• W1981463456 cites W1607563537 @default.
• W1981463456 cites W1967001670 @default.
• W1981463456 cites W1974310343 @default.
• W1981463456 cites W1979742152 @default.
• W1981463456 cites W1988296977 @default.
• W1981463456 cites W1995300477 @default.
• W1981463456 cites W1997100261 @default.
• W1981463456 cites W1997124000 @default.
• W1981463456 cites W2002495550 @default.
• W1981463456 cites W2009308901 @default.
• W1981463456 cites W2017070092 @default.
• W1981463456 cites W2018439132 @default.
• W1981463456 cites W2024717271 @default.
• W1981463456 cites W2033249712 @default.
• W1981463456 cites W2067927161 @default.
• W1981463456 cites W2074538909 @default.
• W1981463456 cites W2081840738 @default.
• W1981463456 cites W2090418707 @default.
• W1981463456 cites W2110053523 @default.
• W1981463456 cites W2111298441 @default.
• W1981463456 cites W2120238028 @default.
• W1981463456 cites W2126145768 @default.
• W1981463456 cites W2136132690 @default.
• W1981463456 cites W2139006460 @default.
• W1981463456 cites W2144469764 @default.
• W1981463456 cites W2156918730 @default.
• W1981463456 cites W2164340229 @default.
• W1981463456 doi "https://doi.org/10.1089/mab.2013.0007" @default.
• W1981463456 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733321" @default.
• W1981463456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23909421" @default.
• W1981463456 hasPublicationYear "2013" @default.
• W1981463456 type Work @default.
• W1981463456 sameAs 1981463456 @default.
• W1981463456 citedByCount "9" @default.
• W1981463456 countsByYear W19814634562015 @default.
• W1981463456 countsByYear W19814634562016 @default.
• W1981463456 countsByYear W19814634562017 @default.
• W1981463456 countsByYear W19814634562018 @default.
• W1981463456 countsByYear W19814634562019 @default.
• W1981463456 countsByYear W19814634562022 @default.
• W1981463456 crossrefType "journal-article" @default.
• W1981463456 hasAuthorship W1981463456A5006295807 @default.
• W1981463456 hasAuthorship W1981463456A5020185674 @default.
• W1981463456 hasAuthorship W1981463456A5020189095 @default.
• W1981463456 hasAuthorship W1981463456A5038995187 @default.
• W1981463456 hasAuthorship W1981463456A5043353316 @default.
• W1981463456 hasAuthorship W1981463456A5053916125 @default.
• W1981463456 hasAuthorship W1981463456A5059312106 @default.
• W1981463456 hasAuthorship W1981463456A5068037677 @default.
• W1981463456 hasAuthorship W1981463456A5071033580 @default.
• W1981463456 hasAuthorship W1981463456A5079094617 @default.
• W1981463456 hasBestOaLocation W19814634562 @default.
• W1981463456 hasConcept C104317684 @default.
• W1981463456 hasConcept C142724271 @default.
• W1981463456 hasConcept C147483822 @default.
• W1981463456 hasConcept C153911025 @default.
• W1981463456 hasConcept C15755913 @default.
• W1981463456 hasConcept C159047783 @default.
• W1981463456 hasConcept C159654299 @default.
• W1981463456 hasConcept C195616568 @default.
• W1981463456 hasConcept C203014093 @default.
• W1981463456 hasConcept C204232928 @default.
• W1981463456 hasConcept C2776415932 @default.
• W1981463456 hasConcept C2778723968 @default.
• W1981463456 hasConcept C2779909307 @default.
• W1981463456 hasConcept C2781137167 @default.
• W1981463456 hasConcept C2781241564 @default.
• W1981463456 hasConcept C4224716 @default.
• W1981463456 hasConcept C542903549 @default.
• W1981463456 hasConcept C55493867 @default.
• W1981463456 hasConcept C71924100 @default.
• W1981463456 hasConcept C81089528 @default.
• W1981463456 hasConcept C86803240 @default.
• W1981463456 hasConceptScore W1981463456C104317684 @default.
• W1981463456 hasConceptScore W1981463456C142724271 @default.
• W1981463456 hasConceptScore W1981463456C147483822 @default.
• W1981463456 hasConceptScore W1981463456C153911025 @default.
• W1981463456 hasConceptScore W1981463456C15755913 @default.
• W1981463456 hasConceptScore W1981463456C159047783 @default.
• W1981463456 hasConceptScore W1981463456C159654299 @default.
• W1981463456 hasConceptScore W1981463456C195616568 @default.
• W1981463456 hasConceptScore W1981463456C203014093 @default.
• W1981463456 hasConceptScore W1981463456C204232928 @default.

• next