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• W1981465486 abstract "We have previously demonstrated that restricting intrauterine food by 50% in 3-mo-old rats produced lower nephron numbers and early-onset hypertension, the latter being normalized by l-arginine administration. In 18-mo-old rats, such restriction increased glomerulosclerosis. In this study, we expanded our investigation, evaluating functional, morphologic, and immunohistochemical parameters in intrauterine-food-restricted 18-mo-old rats, either receiving l-arginine (RA18) or not (R18). Age-matched, non-food-restricted controls were assigned to similar groups with l-arginine (CA18) and without (C18). After weaning, l-arginine was given daily for 17 mo. No functional or morphologic changes were observed in C18 rats. The R18 rats developed early-onset hypertension, which persisted throughout the observation period, as well as significant proteinuria from 12 mo on. In RA18 rats, l-arginine decreased both blood pressure levels and proteinuria, and glomerular diameter was significantly smaller than in R18 rats (115.63 ± 2.2 versus 134.8 ± 1.0 μm, p < 0.05). However, in RA18 rats, glomerular filtration rate remained depressed. Although l-arginine prevented glomerulosclerosis (R18 = 14%, RA18 = 4%; p < 0.05), glomerular expression of fibronectin and desmin was still greater in RA18 rats than in controls. Our data show that, although l-arginine prevented hypertension and proteinuria, glomerular injury still occurred, suggesting that intrauterine food restriction may be one of the leading causes of impaired renal function in adult life." @default.
• W1981465486 created "2016-06-24" @default.
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• W1981465486 date "2005-05-01" @default.
• W1981465486 modified "2023-10-01" @default.
• W1981465486 title "Effects of Intrauterine Food Restriction and Long-Term Dietary Supplementation with l-Arginine on Age-Related Changes in Renal Function and Structure of Rats" @default.
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• W1981465486 doi "https://doi.org/10.1203/01.pdr.0000159514.06939.7e" @default.
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