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- W1981478082 abstract "The whole-cell patch clamp technique was used to characterize voltage- and neurotransmitter-activated currents in the medulloblastoma cell line MHH-MED-3 and cells from tissue slices and primary cultures of two medulloblastoma biopsies. These preparations revealed similar electrophysiological properties. All tested cells displayed 4-aminopyridine-sensitive delayed rectifying K(+) currents, gamma-aminobutyric acid(A) receptor-mediated Cl(-) currents and most of them inward rectifier K(+) currents. Transient inward currents were mainly carried by low-voltage activated T-type Ca(2+) channels in MHH-MED-3 cells, and tetrodotoxin-sensitive Na(+) channels in cells from the primary culture. From these characteristics we conclude that medulloblastoma cells share physiological features with developing cerebellar granule cells at an immature stage." @default.
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- W1981478082 date "2000-06-01" @default.
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- W1981478082 title "Voltage- and γ-aminobutyric acid-activated membrane currents in the human medulloblastoma cell line MHH-MED-3" @default.
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- W1981478082 doi "https://doi.org/10.1016/s0304-3940(00)01134-4" @default.
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