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• W1981482769 abstract "A detailed analysis of the DNA-binding sites of 26 proteins is presented using data from the Nucleic Acid Database (NDB) and the Protein Data Bank (PDB). Chemical and physical properties of the protein-DNA interface, such as polarity, size, shape, and packing, were analysed. The DNA-binding sites shared common features, comprising many discontinuous sequence segments forming hydrophilic surfaces capable of direct and water-mediated hydrogen bonds. These interface sites were compared to those of protein-protein binding sites, revealing them to be more polar, with many more intermolecular hydrogen bonds and buried water molecules than the protein-protein interface sites. By looking at the number and positioning of protein residue-DNA base interactions in a series of interaction footprints, three modes of DNA binding were identified (single-headed, double-headed and enveloping). Six of the eight enzymes in the data set bound in the enveloping mode, with the protein presenting a large interface area effectively wrapped around the DNA. A comparison of structural parameters of the DNA revealed that some values for the bound DNA (including twist, slide and roll) were intermediate of those observed for the unboundB-DNA andA-DNA. The distortion of bound DNA was evaluated by calculating a root-mean-square deviation on fitting to a canonicalB-DNA structure. Major distortions were commonly caused by specific kinks in the DNA sequence, some resulting in the overall bending of the helix. The helix bending affected the dimensions of the grooves in the DNA, allowing the binding of protein elements that would otherwise be unable to make contact. From this structural analysis a preliminary set of rules that govern the bending of the DNA in protein-DNA complexes, are proposed." @default.
• W1981482769 created "2016-06-24" @default.
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• W1981482769 creator A5068874280 @default.
• W1981482769 creator A5071896859 @default.
• W1981482769 creator A5071992108 @default.
• W1981482769 date "1999-04-01" @default.
• W1981482769 modified "2023-10-18" @default.
• W1981482769 title "Protein-DNA interactions: a structural analysis" @default.
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• W1981482769 doi "https://doi.org/10.1006/jmbi.1999.2659" @default.
• W1981482769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10222198" @default.
• W1981482769 hasPublicationYear "1999" @default.
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