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• W1981486972 abstract "Sirtuins (SIRT1-7) are NAD+-dependent histone deacetylases (HDACs) that play an important role in the control of metabolism and proliferation and the development of age-associated diseases like oncologic, cardiovascular and neurodegenerative diseases. Cambinol was originally described as a compound inhibiting the activity of SIRT1 and SIRT2, with efficient anti-tumor activity in vivo. Here, we studied the effects of cambinol on microbial sensing by mouse and human immune cells and on host innate immune responses in vivo. Cambinol inhibited the expression of cytokines (TNF, IL-1β, IL-6, IL-12p40, and IFN-γ), NO and CD40 by macrophages, dendritic cells, splenocytes and whole blood stimulated with a broad range of microbial and inflammasome stimuli. Sirtinol, an inhibitor of SIRT1 and SIRT2 structurally related to cambinol, also decreased macrophage response to TLR stimulation. On the contrary, selective inhibitors of SIRT1 (EX-527 and CHIC-35) and SIRT2 (AGK2 and AK-7) used alone or in combination had no inhibitory effect, suggesting that cambinol and sirtinol act by targeting more than just SIRT1 and SIRT2. Cambinol and sirtinol at anti-inflammatory concentrations also did not inhibit SIRT6 activity in in vitro assay. At the molecular level, cambinol impaired stimulus-induced phosphorylation of MAPKs and upstream MEKs. Going well along with its powerful anti-inflammatory activity, cambinol reduced TNF blood levels and bacteremia and improved survival in preclinical models of endotoxic shock and septic shock. Altogether, our data suggest that pharmacological inhibitors of sirtuins structurally related to cambinol may be of clinical interest to treat inflammatory diseases." @default.
• W1981486972 created "2016-06-24" @default.
• W1981486972 creator A5026299232 @default.
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• W1981486972 date "2013-06-01" @default.
• W1981486972 modified "2023-10-13" @default.
• W1981486972 title "The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock" @default.
• W1981486972 cites W1804408139 @default.
• W1981486972 cites W1964939500 @default.
• W1981486972 cites W1971008373 @default.
• W1981486972 cites W1971565911 @default.
• W1981486972 cites W1974961331 @default.
• W1981486972 cites W1975609596 @default.
• W1981486972 cites W1977936183 @default.
• W1981486972 cites W1979495191 @default.
• W1981486972 cites W1980045113 @default.
• W1981486972 cites W1980607527 @default.
• W1981486972 cites W1980654946 @default.
• W1981486972 cites W1981243375 @default.
• W1981486972 cites W1981687780 @default.
• W1981486972 cites W1984230217 @default.
• W1981486972 cites W1990931780 @default.
• W1981486972 cites W1994942139 @default.
• W1981486972 cites W2002047195 @default.
• W1981486972 cites W2005268326 @default.
• W1981486972 cites W2007415161 @default.
• W1981486972 cites W2007701914 @default.
• W1981486972 cites W2008294957 @default.
• W1981486972 cites W2008776460 @default.
• W1981486972 cites W2013459474 @default.
• W1981486972 cites W2014778624 @default.
• W1981486972 cites W2015361145 @default.
• W1981486972 cites W2025045679 @default.
• W1981486972 cites W2028178274 @default.
• W1981486972 cites W2028401849 @default.
• W1981486972 cites W2029717255 @default.
• W1981486972 cites W2037548688 @default.
• W1981486972 cites W2039482967 @default.
• W1981486972 cites W2040462263 @default.
• W1981486972 cites W2046525356 @default.
• W1981486972 cites W2050449334 @default.
• W1981486972 cites W2052764032 @default.
• W1981486972 cites W2057868230 @default.
• W1981486972 cites W2063084036 @default.
• W1981486972 cites W2063491214 @default.
• W1981486972 cites W2066887945 @default.
• W1981486972 cites W2071666881 @default.
• W1981486972 cites W2074572003 @default.
• W1981486972 cites W2085945129 @default.
• W1981486972 cites W2086256384 @default.
• W1981486972 cites W2088411438 @default.
• W1981486972 cites W2089926265 @default.
• W1981486972 cites W2100587126 @default.
• W1981486972 cites W2101690600 @default.
• W1981486972 cites W2102614059 @default.
• W1981486972 cites W2102635586 @default.
• W1981486972 cites W2102933118 @default.
• W1981486972 cites W2104451222 @default.
• W1981486972 cites W2106222929 @default.
• W1981486972 cites W2107579122 @default.
• W1981486972 cites W2108017291 @default.
• W1981486972 cites W2108573150 @default.
• W1981486972 cites W2108821770 @default.
• W1981486972 cites W2110118637 @default.
• W1981486972 cites W2117411862 @default.
• W1981486972 cites W2118964113 @default.
• W1981486972 cites W2123193437 @default.
• W1981486972 cites W2123257376 @default.
• W1981486972 cites W2126609820 @default.
• W1981486972 cites W2134192536 @default.
• W1981486972 cites W2135711139 @default.
• W1981486972 cites W2138505045 @default.
• W1981486972 cites W2138651252 @default.
• W1981486972 cites W2139058437 @default.
• W1981486972 cites W2140925956 @default.
• W1981486972 cites W2141406553 @default.
• W1981486972 cites W2146955123 @default.
• W1981486972 cites W2148353698 @default.
• W1981486972 cites W2149037606 @default.
• W1981486972 cites W2159957319 @default.
• W1981486972 cites W2162590419 @default.
• W1981486972 cites W2162653540 @default.
• W1981486972 cites W2168244648 @default.
• W1981486972 cites W2168448928 @default.
• W1981486972 cites W2170812501 @default.
• W1981486972 cites W2312699414 @default.
• W1981486972 cites W2324138891 @default.
• W1981486972 cites W2460812166 @default.
• W1981486972 doi "https://doi.org/10.1016/j.bbamcr.2013.03.004" @default.
• W1981486972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23499872" @default.
• W1981486972 hasPublicationYear "2013" @default.
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