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- W1981492068 abstract "A phosphonate monoester, mcarboxyphenyl phenylacetamidomethylphosphonate, has been found to be a specific inhibitor of the class C β-lactamase of Enterobacter cloacae P99. Inactivation is rapid (103 per second per molar concentration) and reactivation very slow (2.2 × 10-6 per second). Apparently concerted with the inactivation, one equivalent (with respect to the enzyme) of mhydroxybenzoate is released. Reactivation is accelerated by hydroxylamine and benzohydroxamate. This suggests that the loss of enzyme activity is due to phosphonylation of an active site functional group. This discovery holds the promise of a new general class of β-lactamase inhibitors and, perhaps, antibiotics." @default.
- W1981492068 created "2016-06-24" @default.
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- W1981492068 date "1989-11-17" @default.
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- W1981492068 title "Inhibition of a Class C β-Lactamase by a Specific Phosphonate Monoester" @default.
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- W1981492068 doi "https://doi.org/10.1126/science.2814513" @default.
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