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• W1981499832 abstract "Background Gastro-esophageal reflux (GOR) may contribute to lung disease in children with cystic fibrosis (CF). There is conflicting evidence regarding the effect of chest physiotherapy (CPT) in the head-down position on GOR. Furthermore, there is currently no evidence on the impact of physiotherapy on GOR as assessed by pH-multichannel intraluminal impedance (pH-MII). Aims (1) To characterize GOR in young children with CF. (2) To determine whether the head-down position during physiotherapy exacerbates GOR. Methods Children were studied using pH-MII monitoring over 24-hr, during which they received two 20-min sessions of CPT. One session was performed in “modified” drainage positions with no head-down tilt and the alternate session in “gravity-assisted” drainage positions, which included 20° head-down tilt. Results Twenty children with CF (8 males), median age 12 months (range 8–34) were recruited. A total of 1,374 reflux episodes were detected in all children, of which 869 (63%) were acid and 505 (37%) were non-acid. Seventy-two percent of the episodes migrated proximally. During CPT, there was no significant difference between total number of reflux episodes in the modified or gravity-assisted positions, median [inter-quartile range (IQR)] 1 (0–2.5) compared to 1 (0.75–3) episode, respectively, P = 0.63. There was also no significant difference between the number of reflux episodes which migrated proximally, median (IQR) 1 (0–2) compared to 0 (0–2) episodes, respectively, P = 0.75. Conclusion In young children with CF, GOR is primarily acidic and proximal migration is common. Physiotherapy in the head-down position does not appear to exacerbate GOR. The impact of GOR on lung disease remains to be elucidated. Pediatr Pulmonol. 2012; 47:119–124. © 2011 Wiley Periodicals, Inc." @default.
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• W1981499832 date "2011-08-24" @default.
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• W1981499832 title "Acid and non-acid reflux during physiotherapy in young children with cystic fibrosis" @default.
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• W1981499832 doi "https://doi.org/10.1002/ppul.21524" @default.
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