FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981502020> ?p ?o ?g. }

• W1981502020 endingPage "1734" @default.
• W1981502020 startingPage "1703" @default.
• W1981502020 abstract "The intracellular mechanisms of regulation of energy fluxes and respiration in contracting heart cells were studied. For this, we investigated the workload dependencies of the rate of oxygen consumption and metabolic parameters in Langendorff-perfused isolated rat hearts.(31)P NMR spectroscopy was used to study the metabolic changes during transition from perfusion with glucose to that with pyruvate with and without active creatine kinase system. The experimental results showed that transition from perfusion with glucose to that with pyruvate increased the phosphocreatine content and stability of its level at increased workloads. Inhibition of creatine kinase reaction by 15-min infusion of iodoacetamide decreased the maximal developed tension and respiration rates by a factor of two.(31)P NMR data were analyzed by a mathematical model of compartmentalized energy transfer, which is independent from the restrictions of the classical concept of creatine kinase equilibrium. The analysis of experimental data by this model shows that metabolic stability-constant levels of phosphocreatine, ATP and inorganic phosphate-at increased energy fluxes is an inherent property of the compartmentalized system. This explains the observed substrate specificity by changes in mitochondrial membrane potential. The decreased maximal respiration rate and maximal work output of the heart with inhibited creatine kinase is well explained by the rise in myoplasmic ADP concentration. This activates the adenylate kinase reaction in the myofibrillar space and in the mitochondria to fulfil the energy transfer and signal transmission functions, usually performed by creatine kinase. The activity of this system, however, is not sufficient to maintain high enough energy fluxes. Therefore, there is a kinetic explanation for the decreased maximal respiration rate of the heart with inhibited creatine kinase: i.e. a kinetically induced switch from an efficient energy transfer pathway (PCr-CK system) to a non-efficient one (myokinase pathway) within the energy transfer network of the cell under conditions of low apparent affinity of mitochondria to ADP in vivo. This may result in a significant decrease in the thermodynamic affinity of compartmentalized ATPase systems and finally in heart failure." @default.
• W1981502020 created "2016-06-24" @default.
• W1981502020 creator A5002203819 @default.
• W1981502020 creator A5002984374 @default.
• W1981502020 creator A5013107785 @default.
• W1981502020 creator A5014053958 @default.
• W1981502020 creator A5021091266 @default.
• W1981502020 creator A5025109057 @default.
• W1981502020 creator A5052482364 @default.
• W1981502020 creator A5056744582 @default.
• W1981502020 creator A5081210142 @default.
• W1981502020 date "2000-09-01" @default.
• W1981502020 modified "2023-09-25" @default.
• W1981502020 title "Metabolic Control of Contractile Performance in Isolated Perfused Rat Heart. Analysis of Experimental Data by Reaction:Diffusion Mathematical Model" @default.
• W1981502020 cites W1489262505 @default.
• W1981502020 cites W1509512816 @default.
• W1981502020 cites W1514524776 @default.
• W1981502020 cites W1520111674 @default.
• W1981502020 cites W1535759476 @default.
• W1981502020 cites W1537523901 @default.
• W1981502020 cites W1540539263 @default.
• W1981502020 cites W1556765696 @default.
• W1981502020 cites W1568377212 @default.
• W1981502020 cites W1569404945 @default.
• W1981502020 cites W1571129442 @default.
• W1981502020 cites W1586233686 @default.
• W1981502020 cites W1591694509 @default.
• W1981502020 cites W1661549035 @default.
• W1981502020 cites W1762977483 @default.
• W1981502020 cites W1775749144 @default.
• W1981502020 cites W1849159432 @default.
• W1981502020 cites W1935060748 @default.
• W1981502020 cites W1966991432 @default.
• W1981502020 cites W1967213708 @default.
• W1981502020 cites W1969639141 @default.
• W1981502020 cites W1970450488 @default.
• W1981502020 cites W1976701283 @default.
• W1981502020 cites W1981680723 @default.
• W1981502020 cites W1983090416 @default.
• W1981502020 cites W1989675469 @default.
• W1981502020 cites W1989693351 @default.
• W1981502020 cites W1990220729 @default.
• W1981502020 cites W1991762116 @default.
• W1981502020 cites W1992684611 @default.
• W1981502020 cites W1993371553 @default.
• W1981502020 cites W1994197068 @default.
• W1981502020 cites W2002231234 @default.
• W1981502020 cites W2007552499 @default.
• W1981502020 cites W2014167033 @default.
• W1981502020 cites W2024967983 @default.
• W1981502020 cites W2026316964 @default.
• W1981502020 cites W2032749768 @default.
• W1981502020 cites W2034143248 @default.
• W1981502020 cites W2038327263 @default.
• W1981502020 cites W2040886273 @default.
• W1981502020 cites W2042187394 @default.
• W1981502020 cites W2042843202 @default.
• W1981502020 cites W2044292165 @default.
• W1981502020 cites W2044726034 @default.
• W1981502020 cites W2051573229 @default.
• W1981502020 cites W2053116782 @default.
• W1981502020 cites W2055685270 @default.
• W1981502020 cites W2056511146 @default.
• W1981502020 cites W2057861770 @default.
• W1981502020 cites W2059445586 @default.
• W1981502020 cites W2060801398 @default.
• W1981502020 cites W2063980449 @default.
• W1981502020 cites W2074570665 @default.
• W1981502020 cites W2076802214 @default.
• W1981502020 cites W2077930835 @default.
• W1981502020 cites W2078848135 @default.
• W1981502020 cites W2085373248 @default.
• W1981502020 cites W2086661624 @default.
• W1981502020 cites W2088054367 @default.
• W1981502020 cites W2088957259 @default.
• W1981502020 cites W2124009251 @default.
• W1981502020 cites W2128021010 @default.
• W1981502020 cites W2129533522 @default.
• W1981502020 cites W2132795937 @default.
• W1981502020 cites W2157022764 @default.
• W1981502020 cites W2175290961 @default.
• W1981502020 cites W2188647161 @default.
• W1981502020 cites W2214334965 @default.
• W1981502020 cites W2250961987 @default.
• W1981502020 cites W2276148590 @default.
• W1981502020 cites W2284465464 @default.
• W1981502020 cites W2285739291 @default.
• W1981502020 cites W2367587124 @default.
• W1981502020 cites W3093453526 @default.
• W1981502020 cites W340429596 @default.
• W1981502020 cites W4250841709 @default.
• W1981502020 cites W4252592885 @default.
• W1981502020 cites W4254506477 @default.
• W1981502020 cites W621402454 @default.
• W1981502020 cites W77904532 @default.
• W1981502020 cites W98195451 @default.
• W1981502020 doi "https://doi.org/10.1006/jmcc.2000.1207" @default.
• W1981502020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10966833" @default.

• next