Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981502053> ?p ?o ?g. }
- W1981502053 endingPage "142" @default.
- W1981502053 startingPage "133" @default.
- W1981502053 abstract "The effects of norepinephrine on ion fluxes in rat brain cortical slices have now been ascertained. 22Na efflux and 42K influx are enhanced by norepinephrine. The increase in ion fluxes can be blocked by ouabain, phentolamine and propranolol, suggesting that the catecholamine activates a membrane sodium pump by a receptor-mediated step. The facilitation of 22Na efflux is stereospecific as demonstrated by the very weak action of d-norepinephrine at 10 −5 M concentration. Various α-adrenergic and β-adrenergic receptor agonists, including oxymetazoline, naphazoline, clonidine, tramazoline, methoxamine, phenylephrine, l-isoproterenol and methoxyphenamine are potent stimulants of the sodium pump as demonstrated by their enhancement of ion fluxes in rat brain cortical slices. Our results are consistent with the hypothesis that norepinephrine hyperpolarizes central neurons by activating an ouabain-sensitive, receptor-mediated sodium pump." @default.
- W1981502053 created "2016-06-24" @default.
- W1981502053 creator A5035655971 @default.
- W1981502053 creator A5044310168 @default.
- W1981502053 creator A5088006369 @default.
- W1981502053 date "1982-03-01" @default.
- W1981502053 modified "2023-10-18" @default.
- W1981502053 title "The effect of α-, β adrenergic receptor agonists and antagonists on the efflux of 22Na and uptake of 42K by rat brain cortical slices" @default.
- W1981502053 cites W1775749144 @default.
- W1981502053 cites W1970770147 @default.
- W1981502053 cites W1986945166 @default.
- W1981502053 cites W1995493454 @default.
- W1981502053 cites W1996202212 @default.
- W1981502053 cites W1997481436 @default.
- W1981502053 cites W2007539578 @default.
- W1981502053 cites W2009490000 @default.
- W1981502053 cites W2023140990 @default.
- W1981502053 cites W2025802903 @default.
- W1981502053 cites W2029411878 @default.
- W1981502053 cites W2029510519 @default.
- W1981502053 cites W2045517170 @default.
- W1981502053 cites W2050645918 @default.
- W1981502053 cites W2061456966 @default.
- W1981502053 cites W2065203161 @default.
- W1981502053 cites W2075191226 @default.
- W1981502053 cites W2077721250 @default.
- W1981502053 cites W2078305204 @default.
- W1981502053 cites W2081860406 @default.
- W1981502053 cites W2088914168 @default.
- W1981502053 cites W2097294152 @default.
- W1981502053 cites W2097710542 @default.
- W1981502053 cites W2277327634 @default.
- W1981502053 cites W2403752766 @default.
- W1981502053 cites W2403763994 @default.
- W1981502053 doi "https://doi.org/10.1016/0006-8993(82)90040-3" @default.
- W1981502053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6121608" @default.
- W1981502053 hasPublicationYear "1982" @default.
- W1981502053 type Work @default.
- W1981502053 sameAs 1981502053 @default.
- W1981502053 citedByCount "9" @default.
- W1981502053 countsByYear W19815020532012 @default.
- W1981502053 crossrefType "journal-article" @default.
- W1981502053 hasAuthorship W1981502053A5035655971 @default.
- W1981502053 hasAuthorship W1981502053A5044310168 @default.
- W1981502053 hasAuthorship W1981502053A5088006369 @default.
- W1981502053 hasConcept C126322002 @default.
- W1981502053 hasConcept C134018914 @default.
- W1981502053 hasConcept C170493617 @default.
- W1981502053 hasConcept C178790620 @default.
- W1981502053 hasConcept C185592680 @default.
- W1981502053 hasConcept C200082930 @default.
- W1981502053 hasConcept C2777952589 @default.
- W1981502053 hasConcept C2778151854 @default.
- W1981502053 hasConcept C2778514916 @default.
- W1981502053 hasConcept C2778938600 @default.
- W1981502053 hasConcept C2779133857 @default.
- W1981502053 hasConcept C2780042274 @default.
- W1981502053 hasConcept C2780253649 @default.
- W1981502053 hasConcept C2780745239 @default.
- W1981502053 hasConcept C40465926 @default.
- W1981502053 hasConcept C513476851 @default.
- W1981502053 hasConcept C537181965 @default.
- W1981502053 hasConcept C55493867 @default.
- W1981502053 hasConcept C71924100 @default.
- W1981502053 hasConcept C84393581 @default.
- W1981502053 hasConcept C86803240 @default.
- W1981502053 hasConcept C98274493 @default.
- W1981502053 hasConceptScore W1981502053C126322002 @default.
- W1981502053 hasConceptScore W1981502053C134018914 @default.
- W1981502053 hasConceptScore W1981502053C170493617 @default.
- W1981502053 hasConceptScore W1981502053C178790620 @default.
- W1981502053 hasConceptScore W1981502053C185592680 @default.
- W1981502053 hasConceptScore W1981502053C200082930 @default.
- W1981502053 hasConceptScore W1981502053C2777952589 @default.
- W1981502053 hasConceptScore W1981502053C2778151854 @default.
- W1981502053 hasConceptScore W1981502053C2778514916 @default.
- W1981502053 hasConceptScore W1981502053C2778938600 @default.
- W1981502053 hasConceptScore W1981502053C2779133857 @default.
- W1981502053 hasConceptScore W1981502053C2780042274 @default.
- W1981502053 hasConceptScore W1981502053C2780253649 @default.
- W1981502053 hasConceptScore W1981502053C2780745239 @default.
- W1981502053 hasConceptScore W1981502053C40465926 @default.
- W1981502053 hasConceptScore W1981502053C513476851 @default.
- W1981502053 hasConceptScore W1981502053C537181965 @default.
- W1981502053 hasConceptScore W1981502053C55493867 @default.
- W1981502053 hasConceptScore W1981502053C71924100 @default.
- W1981502053 hasConceptScore W1981502053C84393581 @default.
- W1981502053 hasConceptScore W1981502053C86803240 @default.
- W1981502053 hasConceptScore W1981502053C98274493 @default.
- W1981502053 hasIssue "1" @default.
- W1981502053 hasLocation W19815020531 @default.
- W1981502053 hasLocation W19815020532 @default.
- W1981502053 hasOpenAccess W1981502053 @default.
- W1981502053 hasPrimaryLocation W19815020531 @default.
- W1981502053 hasRelatedWork W1931482045 @default.
- W1981502053 hasRelatedWork W1941863415 @default.
- W1981502053 hasRelatedWork W1981502053 @default.
- W1981502053 hasRelatedWork W2003670070 @default.