FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981505639> ?p ?o ?g. }

• W1981505639 endingPage "R1184" @default.
• W1981505639 startingPage "R1175" @default.
• W1981505639 abstract "Luminal nutrients stimulate structural and functional regeneration in the intestine through mechanisms thought to involve insulin-like growth factor I (IGF-I) and glucagon-like peptide-2 (GLP-2). We investigated the relationship between IGF-I and GLP-2 responses and mucosal growth in rats fasted for 48 h and then refed for 2 or 4 days by continuous intravenous or intragastric infusion or ad libitum feeding. Fasting induced significant decreases in body weight, plasma concentrations of IGF-I and bioactive GLP-2, jejunal mucosal cellularity (mass, protein, DNA, and villus height), IGF-I mRNA, and ileal proglucagon mRNA. Plasma IGF-I concentration was restored to fed levels with 2 days of ad libitum refeeding but not with 4 days of intravenous or intragastric refeeding. Administration of an inhibitor of endogenous GLP-2 (rat GLP-2 3–33 ) during ad libitum refeeding partially attenuated mucosal growth and prevented the increase in plasma IGF-I to fed levels; however, plasma GLP-2 and jejunal IGF-I mRNA were restored to fed levels. Intragastric refeeding restored intestinal cellularity and functional capacity (sucrase activity and sodium-glucose transporter-1 expression) to fed levels, whereas intravenous refeeding had no effect. Intestinal regeneration after 4 days of intragastric or 2 days of ad libitum refeeding was positively associated with increases in plasma concentrations of GLP-2 and jejunal IGF-I mRNA. These data suggest that luminal nutrients stimulate intestinal growth, in part, by increased expression of both GLP-2 and IGF-I." @default.
• W1981505639 created "2016-06-24" @default.
• W1981505639 creator A5040736172 @default.
• W1981505639 creator A5074292548 @default.
• W1981505639 creator A5078185313 @default.
• W1981505639 creator A5082989831 @default.
• W1981505639 creator A5085434984 @default.
• W1981505639 creator A5088808481 @default.
• W1981505639 date "2008-04-01" @default.
• W1981505639 modified "2023-10-17" @default.
• W1981505639 title "Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats" @default.
• W1981505639 cites W1604800606 @default.
• W1981505639 cites W1683752523 @default.
• W1981505639 cites W1922253981 @default.
• W1981505639 cites W1971158032 @default.
• W1981505639 cites W1977779461 @default.
• W1981505639 cites W2006294206 @default.
• W1981505639 cites W2006578936 @default.
• W1981505639 cites W2019357285 @default.
• W1981505639 cites W2022663768 @default.
• W1981505639 cites W2024501012 @default.
• W1981505639 cites W2029056840 @default.
• W1981505639 cites W2029770320 @default.
• W1981505639 cites W2035356073 @default.
• W1981505639 cites W2037945604 @default.
• W1981505639 cites W2042033555 @default.
• W1981505639 cites W2045586733 @default.
• W1981505639 cites W2049837588 @default.
• W1981505639 cites W2066201820 @default.
• W1981505639 cites W2082633828 @default.
• W1981505639 cites W2088954563 @default.
• W1981505639 cites W2095092379 @default.
• W1981505639 cites W2100093779 @default.
• W1981505639 cites W2107277218 @default.
• W1981505639 cites W2109745718 @default.
• W1981505639 cites W2124148070 @default.
• W1981505639 cites W2127068727 @default.
• W1981505639 cites W2135799781 @default.
• W1981505639 cites W2136575312 @default.
• W1981505639 cites W2145242908 @default.
• W1981505639 cites W2168284970 @default.
• W1981505639 cites W2175314136 @default.
• W1981505639 cites W2182330003 @default.
• W1981505639 cites W2277714145 @default.
• W1981505639 cites W2286656038 @default.
• W1981505639 cites W2325600788 @default.
• W1981505639 cites W2346582744 @default.
• W1981505639 doi "https://doi.org/10.1152/ajpregu.00238.2007" @default.
• W1981505639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18256135" @default.
• W1981505639 hasPublicationYear "2008" @default.
• W1981505639 type Work @default.
• W1981505639 sameAs 1981505639 @default.
• W1981505639 citedByCount "59" @default.
• W1981505639 countsByYear W19815056392012 @default.
• W1981505639 countsByYear W19815056392013 @default.
• W1981505639 countsByYear W19815056392014 @default.
• W1981505639 countsByYear W19815056392015 @default.
• W1981505639 countsByYear W19815056392016 @default.
• W1981505639 countsByYear W19815056392017 @default.
• W1981505639 countsByYear W19815056392018 @default.
• W1981505639 countsByYear W19815056392019 @default.
• W1981505639 countsByYear W19815056392020 @default.
• W1981505639 countsByYear W19815056392021 @default.
• W1981505639 crossrefType "journal-article" @default.
• W1981505639 hasAuthorship W1981505639A5040736172 @default.
• W1981505639 hasAuthorship W1981505639A5074292548 @default.
• W1981505639 hasAuthorship W1981505639A5078185313 @default.
• W1981505639 hasAuthorship W1981505639A5082989831 @default.
• W1981505639 hasAuthorship W1981505639A5085434984 @default.
• W1981505639 hasAuthorship W1981505639A5088808481 @default.
• W1981505639 hasConcept C104317684 @default.
• W1981505639 hasConcept C105580179 @default.
• W1981505639 hasConcept C126322002 @default.
• W1981505639 hasConcept C134018914 @default.
• W1981505639 hasConcept C170493617 @default.
• W1981505639 hasConcept C185592680 @default.
• W1981505639 hasConcept C2775960820 @default.
• W1981505639 hasConcept C2776398474 @default.
• W1981505639 hasConcept C2777180221 @default.
• W1981505639 hasConcept C2777226302 @default.
• W1981505639 hasConcept C2777882243 @default.
• W1981505639 hasConcept C2778563252 @default.
• W1981505639 hasConcept C2779281246 @default.
• W1981505639 hasConcept C2779306644 @default.
• W1981505639 hasConcept C2780378035 @default.
• W1981505639 hasConcept C2780689927 @default.
• W1981505639 hasConcept C2780768396 @default.
• W1981505639 hasConcept C2781101655 @default.
• W1981505639 hasConcept C2781219945 @default.
• W1981505639 hasConcept C551997983 @default.
• W1981505639 hasConcept C55493867 @default.
• W1981505639 hasConcept C555293320 @default.
• W1981505639 hasConcept C71924100 @default.
• W1981505639 hasConcept C86803240 @default.
• W1981505639 hasConceptScore W1981505639C104317684 @default.
• W1981505639 hasConceptScore W1981505639C105580179 @default.
• W1981505639 hasConceptScore W1981505639C126322002 @default.
• W1981505639 hasConceptScore W1981505639C134018914 @default.

• next