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- W1981506324 abstract "In this study, we report p-coumaric acid as novel and effective response marker for indirectly measuring the levels of hypoxia in normal primary bronchial epithelial cells. We developed a simple and rapid technique based on hydrophilic interaction chromatography-electrospray ionization-mass spectrometry (HILIC-ESI–MS). During 168 h of hypoxia without induction of reactive oxygen species (ROS), an almost linear increase of p-coumaric acid levels was observed. We interpret the increasing p-coumaric acid concentrations during hypoxia as a result of cell damage, triggered by reduced co-enzyme Q10 levels, because the oxidative cascade was not able to supply sufficient energy. The HILIC-ESI–MS assay within p-coumaric acid exhibited a linear dynamic range from 60 to 610 ng/μL with correlation coefficient of 0.9998. The precision of the assay was ≤15% RSD and method accuracies between 97 and 108%." @default.
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- W1981506324 date "2012-09-01" @default.
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- W1981506324 title "MitoNuc2Dx — Analyzing the mitochondrial genes encoded in the nuclear genome to assess their possible association with mitochondrial disorders" @default.
- W1981506324 doi "https://doi.org/10.1016/j.mito.2012.07.092" @default.
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