FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981506566> ?p ?o ?g. }

• W1981506566 endingPage "911" @default.
• W1981506566 startingPage "897" @default.
• W1981506566 abstract "In Drosophila and vertebrates, suppressor of fused (Su(fu)) proteins act as negative regulators of the Gli/Ci transcription factors, which mediate the transcriptional effects of Hh signalling.We sought for novel partners of Su(fu) in fly using the two-hybrid method. Most of the Su(fu) interactors thus identified are (or are likely to be) able to enter the nucleus. We focused on one of these putative partners, dMLF, which resembles vertebrate myelodysplasia/myeloid leukaemia factors 1 and 2. We demonstrate that dMLF binds specifically to Su(fu) in vitro and in vivo. Using a novel anti-dMLF antibody, we showed, that dMLF is a nuclear, chromosome-associated protein. We over-expressed a dMLF transgene in fly using an inducible expression system and showed that dMLF over-expression disrupts normal development, leading to either a lethal phenotype or adult structural defects associated with apoptosis and increased DNA synthesis. Furthermore, the dMLF-induced eye phenotype is enhanced by the loss of Su(fu) function, suggesting a genetic interaction between Su(fu) and dMLF.We propose that dSu(fu) and dMLF act together at the transcriptional level to coordinate patterning and proliferation during development." @default.
• W1981506566 created "2016-06-24" @default.
• W1981506566 creator A5004939291 @default.
• W1981506566 creator A5039038898 @default.
• W1981506566 creator A5060385764 @default.
• W1981506566 creator A5066714316 @default.
• W1981506566 creator A5070163495 @default.
• W1981506566 creator A5087273226 @default.
• W1981506566 date "2003-10-30" @default.
• W1981506566 modified "2023-10-18" @default.
• W1981506566 title "Over-expression of a novel nuclear interactor of Suppressor of fused, the<i>Drosophila</i>myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis" @default.
• W1981506566 cites W129013773 @default.
• W1981506566 cites W1523919884 @default.
• W1981506566 cites W1543890504 @default.
• W1981506566 cites W1566332707 @default.
• W1981506566 cites W1567403197 @default.
• W1981506566 cites W1659071674 @default.
• W1981506566 cites W1964318436 @default.
• W1981506566 cites W1966715577 @default.
• W1981506566 cites W1969477031 @default.
• W1981506566 cites W1974035062 @default.
• W1981506566 cites W1982656482 @default.
• W1981506566 cites W1985027918 @default.
• W1981506566 cites W1985890098 @default.
• W1981506566 cites W1991100707 @default.
• W1981506566 cites W1991583885 @default.
• W1981506566 cites W1995338672 @default.
• W1981506566 cites W1997905438 @default.
• W1981506566 cites W2008329190 @default.
• W1981506566 cites W2008444931 @default.
• W1981506566 cites W2016021790 @default.
• W1981506566 cites W2026302885 @default.
• W1981506566 cites W2039640335 @default.
• W1981506566 cites W2044224432 @default.
• W1981506566 cites W2045105811 @default.
• W1981506566 cites W2047147796 @default.
• W1981506566 cites W2050749151 @default.
• W1981506566 cites W2053277371 @default.
• W1981506566 cites W2053959638 @default.
• W1981506566 cites W2069151092 @default.
• W1981506566 cites W2071993841 @default.
• W1981506566 cites W2072714763 @default.
• W1981506566 cites W2086419330 @default.
• W1981506566 cites W2088068726 @default.
• W1981506566 cites W2099268945 @default.
• W1981506566 cites W2104450392 @default.
• W1981506566 cites W2107308666 @default.
• W1981506566 cites W2108707301 @default.
• W1981506566 cites W2110643873 @default.
• W1981506566 cites W2111197864 @default.
• W1981506566 cites W2115655777 @default.
• W1981506566 cites W2118132057 @default.
• W1981506566 cites W2119326753 @default.
• W1981506566 cites W2131906224 @default.
• W1981506566 cites W2140507884 @default.
• W1981506566 cites W2141650885 @default.
• W1981506566 cites W2142414089 @default.
• W1981506566 cites W2151029758 @default.
• W1981506566 cites W2158991992 @default.
• W1981506566 cites W2159858422 @default.
• W1981506566 cites W2167021532 @default.
• W1981506566 cites W2170048206 @default.
• W1981506566 cites W2171802796 @default.
• W1981506566 cites W2219575153 @default.
• W1981506566 cites W2342738149 @default.
• W1981506566 cites W321588607 @default.
• W1981506566 doi "https://doi.org/10.1046/j.1365-2443.2003.00685.x" @default.
• W1981506566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14622141" @default.
• W1981506566 hasPublicationYear "2003" @default.
• W1981506566 type Work @default.
• W1981506566 sameAs 1981506566 @default.
• W1981506566 citedByCount "15" @default.
• W1981506566 countsByYear W19815065662012 @default.
• W1981506566 countsByYear W19815065662014 @default.
• W1981506566 countsByYear W19815065662015 @default.
• W1981506566 countsByYear W19815065662017 @default.
• W1981506566 countsByYear W19815065662023 @default.
• W1981506566 crossrefType "journal-article" @default.
• W1981506566 hasAuthorship W1981506566A5004939291 @default.
• W1981506566 hasAuthorship W1981506566A5039038898 @default.
• W1981506566 hasAuthorship W1981506566A5060385764 @default.
• W1981506566 hasAuthorship W1981506566A5066714316 @default.
• W1981506566 hasAuthorship W1981506566A5070163495 @default.
• W1981506566 hasAuthorship W1981506566A5087273226 @default.
• W1981506566 hasConcept C102230213 @default.
• W1981506566 hasConcept C104317684 @default.
• W1981506566 hasConcept C127716648 @default.
• W1981506566 hasConcept C153911025 @default.
• W1981506566 hasConcept C179185449 @default.
• W1981506566 hasConcept C2779282312 @default.
• W1981506566 hasConcept C29512474 @default.
• W1981506566 hasConcept C40692019 @default.
• W1981506566 hasConcept C502942594 @default.
• W1981506566 hasConcept C54355233 @default.
• W1981506566 hasConcept C86339819 @default.
• W1981506566 hasConcept C86803240 @default.
• W1981506566 hasConcept C95444343 @default.
• W1981506566 hasConceptScore W1981506566C102230213 @default.

• next