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- W1981506996 abstract "Several studies have been conducted to examine the association between PPAR-γ2 Pro12Ala polymorphism and polycystic ovary syndrome (PCOS), but the results remain inconsistent. To make a more precise estimation of the relationship, a meta-analysis was performed. In the current meta-analysis, a total of 17 case–control studies, including 2176 cases and 2373 controls, were selected. Odds ratios (ORs) and 95% confidence intervals (CIs) for Pro/Ala + Ala/Ala versus Pro/Pro genotype in all population and different nationality groups, and homeostasis model assessment-insulin resistance (HOMA-IR) of different genotype were evaluated. In the overall analysis, significant association between PPAR-γ2 Pro12Ala polymorphism and reduced risk of PCOS was observed (OR = 0.75; 95%CI, 0.62–0.91; p = 0.003). Stratified analysis showed that significantly strong association was presented only in Europeans (OR = 0.74; 95%CI, 0.60–0.90; p = 0.003), but not in Asians (OR = 0.86; 95%CI, 0.51–1.43; p = 0.56). Additionally, carrying the Ala12 allele was not associated with HOMA-IR in PCOS patients (OR = − 0.29; 95%CI, − 0.82–0.24; p = 0.29). This meta-analysis supported that PPAR-γ2 Pro12Ala polymorphism was capable of reducing polycystic ovary syndrome risk in Europeans, but not in Asians." @default.
- W1981506996 created "2016-06-24" @default.
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- W1981506996 date "2012-07-01" @default.
- W1981506996 modified "2023-10-14" @default.
- W1981506996 title "Association between the Pro12Ala polymorphism of PPAR-γ gene and the polycystic ovary syndrome: A meta-analysis of case–control studies" @default.
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- W1981506996 doi "https://doi.org/10.1016/j.gene.2012.04.083" @default.
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