Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981507072> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1981507072 endingPage "309" @default.
- W1981507072 startingPage "299" @default.
- W1981507072 abstract "Leukaemogenesis induced with chemical carcinogens and hormones was studied in intact and ovariectomized mice of the ICRC strain which is susceptible to spontaneous development of both breast cancer and leukaemia and the Strong A strain susceptible only to breast cancer and not to leukaemia. In ovariectomized females oestradiol was administered at two dose levels (i) 1 μg oestradiol/day for 30 days, (ii) 10 μg oestradiol/day for 30 days. The effect of oestradiol (1 μg/day) and progesterone (1 mg/day) for 30 days was also studied. In one group, two pituitaries of the syngeneic male mice were implanted subcutaneously on the right inguinal pair of mammary glands. Enhancing effect of 20-MCA on leukaemogenesis was seen in intact strain ICRC mice and not in ovariectomized mice. However, administration of hormones, either oestradiol alone or in combination with progesterone, or by the way of pituitary grafts, to these carcinogen treated ovariectomized females increased the incidence of leukaemia with a shorter latent period. Although 20-MCA could induce leukaemogenesis in Strong A ovariectomized females, further treatment with hormones, either with pituitary graft or with oestradiol, failed to promote leukaemogenesis. The highest leukaemia incidence in strain A ovariectomized females was observed in the group treated with a balanced dose of oestradiol and progesterone. The present experimental findings in the ICRC and Strong A strains suggest specific differential responses of different strains of mice to the action of carcinogen and hormones for the induction of leukaemogenesis." @default.
- W1981507072 created "2016-06-24" @default.
- W1981507072 creator A5048919786 @default.
- W1981507072 creator A5075157408 @default.
- W1981507072 date "1973-10-01" @default.
- W1981507072 modified "2023-10-06" @default.
- W1981507072 title "Influence of Hormones and Chemical Carcinogen on Murine Leukaemia" @default.
- W1981507072 cites W1496192507 @default.
- W1981507072 cites W1530521584 @default.
- W1981507072 cites W1560409254 @default.
- W1981507072 cites W1602762301 @default.
- W1981507072 cites W1632375680 @default.
- W1981507072 cites W1751893878 @default.
- W1981507072 cites W1824092230 @default.
- W1981507072 cites W1888266918 @default.
- W1981507072 cites W1909638232 @default.
- W1981507072 cites W1996723320 @default.
- W1981507072 cites W2014598124 @default.
- W1981507072 cites W2047997434 @default.
- W1981507072 cites W2084440888 @default.
- W1981507072 cites W2117667564 @default.
- W1981507072 cites W2159007247 @default.
- W1981507072 cites W2170433304 @default.
- W1981507072 cites W2330216153 @default.
- W1981507072 cites W2395349345 @default.
- W1981507072 cites W2418649704 @default.
- W1981507072 cites W2424242144 @default.
- W1981507072 cites W2471031814 @default.
- W1981507072 cites W268771548 @default.
- W1981507072 cites W4243066550 @default.
- W1981507072 cites W575879138 @default.
- W1981507072 cites W1918196550 @default.
- W1981507072 doi "https://doi.org/10.1038/bjc.1973.152" @default.
- W1981507072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2008909" @default.
- W1981507072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4759938" @default.
- W1981507072 hasPublicationYear "1973" @default.
- W1981507072 type Work @default.
- W1981507072 sameAs 1981507072 @default.
- W1981507072 citedByCount "3" @default.
- W1981507072 crossrefType "journal-article" @default.
- W1981507072 hasAuthorship W1981507072A5048919786 @default.
- W1981507072 hasAuthorship W1981507072A5075157408 @default.
- W1981507072 hasBestOaLocation W19815070722 @default.
- W1981507072 hasConcept C114246631 @default.
- W1981507072 hasConcept C126322002 @default.
- W1981507072 hasConcept C134018914 @default.
- W1981507072 hasConcept C2777164284 @default.
- W1981507072 hasConcept C2777658017 @default.
- W1981507072 hasConcept C54355233 @default.
- W1981507072 hasConcept C71315377 @default.
- W1981507072 hasConcept C71924100 @default.
- W1981507072 hasConcept C8264082 @default.
- W1981507072 hasConcept C86803240 @default.
- W1981507072 hasConceptScore W1981507072C114246631 @default.
- W1981507072 hasConceptScore W1981507072C126322002 @default.
- W1981507072 hasConceptScore W1981507072C134018914 @default.
- W1981507072 hasConceptScore W1981507072C2777164284 @default.
- W1981507072 hasConceptScore W1981507072C2777658017 @default.
- W1981507072 hasConceptScore W1981507072C54355233 @default.
- W1981507072 hasConceptScore W1981507072C71315377 @default.
- W1981507072 hasConceptScore W1981507072C71924100 @default.
- W1981507072 hasConceptScore W1981507072C8264082 @default.
- W1981507072 hasConceptScore W1981507072C86803240 @default.
- W1981507072 hasIssue "4" @default.
- W1981507072 hasLocation W19815070721 @default.
- W1981507072 hasLocation W19815070722 @default.
- W1981507072 hasLocation W19815070723 @default.
- W1981507072 hasLocation W19815070724 @default.
- W1981507072 hasOpenAccess W1981507072 @default.
- W1981507072 hasPrimaryLocation W19815070721 @default.
- W1981507072 hasRelatedWork W2002384464 @default.
- W1981507072 hasRelatedWork W2024405772 @default.
- W1981507072 hasRelatedWork W2064836726 @default.
- W1981507072 hasRelatedWork W2071688816 @default.
- W1981507072 hasRelatedWork W2085668963 @default.
- W1981507072 hasRelatedWork W2090136455 @default.
- W1981507072 hasRelatedWork W2092722075 @default.
- W1981507072 hasRelatedWork W2108578925 @default.
- W1981507072 hasRelatedWork W2109773872 @default.
- W1981507072 hasRelatedWork W2167902350 @default.
- W1981507072 hasVolume "28" @default.
- W1981507072 isParatext "false" @default.
- W1981507072 isRetracted "false" @default.
- W1981507072 magId "1981507072" @default.
- W1981507072 workType "article" @default.