FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981507449> ?p ?o ?g. }

• W1981507449 endingPage "e98554" @default.
• W1981507449 startingPage "e98554" @default.
• W1981507449 abstract "MutL is a multi-domain protein comprising an N-terminal ATPase domain (NTD) and C-terminal dimerization domain (CTD), connected with flexible linker regions, that plays a key role in DNA mismatch repair. To expand understanding of the regulation mechanism underlying MutL endonuclease activity, our NMR-based study investigated interactions between the CTD of MutL, derived from the hyperthermophilic bacterium Aquifex aeolicus (aqMutL-CTD), and putative binding molecules. Chemical shift perturbation analysis with the model structure of aqMutL-CTD and circular dichroism results revealed that tight Zn2+ binding increased thermal stability without changing secondary structures to function at high temperatures. Peak intensity analysis exploiting the paramagnetic relaxation enhancement effect indicated the binding site for Mn2+, which shared binding sites for Zn2+. The coexistence of these two metal ions appears to be important for the function of MutL. Chemical shift perturbation analysis revealed a novel ATP binding site in aqMutL-CTD. A docking simulation incorporating the chemical shift perturbation data provided a putative scheme for the intermolecular interactions between aqMutL-CTD and ATP. We proposed a simple and understandable mechanical model for the regulation of MutL endonuclease activity in MMR based on the relative concentrations of ATP and CTD through ATP binding-regulated interdomain interactions between CTD and NTD." @default.
• W1981507449 created "2016-06-24" @default.
• W1981507449 creator A5022600763 @default.
• W1981507449 creator A5023480923 @default.
• W1981507449 creator A5042559866 @default.
• W1981507449 creator A5052409368 @default.
• W1981507449 creator A5056125632 @default.
• W1981507449 creator A5056515301 @default.
• W1981507449 creator A5059911902 @default.
• W1981507449 creator A5063209025 @default.
• W1981507449 creator A5065783054 @default.
• W1981507449 creator A5076117140 @default.
• W1981507449 creator A5079410680 @default.
• W1981507449 creator A5084385524 @default.
• W1981507449 date "2014-06-05" @default.
• W1981507449 modified "2023-09-26" @default.
• W1981507449 title "NMR Characterization of the Interaction of the Endonuclease Domain of MutL with Divalent Metal Ions and ATP" @default.
• W1981507449 cites W1974378317 @default.
• W1981507449 cites W1975781028 @default.
• W1981507449 cites W1977284533 @default.
• W1981507449 cites W1983021936 @default.
• W1981507449 cites W1983976007 @default.
• W1981507449 cites W1986347357 @default.
• W1981507449 cites W1996914290 @default.
• W1981507449 cites W2004235182 @default.
• W1981507449 cites W2004723279 @default.
• W1981507449 cites W2009608382 @default.
• W1981507449 cites W2015642465 @default.
• W1981507449 cites W2022671515 @default.
• W1981507449 cites W2024331929 @default.
• W1981507449 cites W2024946505 @default.
• W1981507449 cites W2025252058 @default.
• W1981507449 cites W2026866678 @default.
• W1981507449 cites W2030343674 @default.
• W1981507449 cites W2038470696 @default.
• W1981507449 cites W2042243713 @default.
• W1981507449 cites W2043546654 @default.
• W1981507449 cites W2049861471 @default.
• W1981507449 cites W2054755153 @default.
• W1981507449 cites W2060958156 @default.
• W1981507449 cites W2070510164 @default.
• W1981507449 cites W2073115736 @default.
• W1981507449 cites W2073920564 @default.
• W1981507449 cites W2075271539 @default.
• W1981507449 cites W2076300945 @default.
• W1981507449 cites W2079666836 @default.
• W1981507449 cites W2088703187 @default.
• W1981507449 cites W2089068108 @default.
• W1981507449 cites W2110100961 @default.
• W1981507449 cites W2112331024 @default.
• W1981507449 cites W2112418305 @default.
• W1981507449 cites W2124316420 @default.
• W1981507449 cites W2131288855 @default.
• W1981507449 cites W2141323033 @default.
• W1981507449 cites W2166925654 @default.
• W1981507449 cites W2169821755 @default.
• W1981507449 cites W2883755802 @default.
• W1981507449 cites W322900245 @default.
• W1981507449 cites W607135683 @default.
• W1981507449 doi "https://doi.org/10.1371/journal.pone.0098554" @default.
• W1981507449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4047009" @default.
• W1981507449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24901533" @default.
• W1981507449 hasPublicationYear "2014" @default.
• W1981507449 type Work @default.
• W1981507449 sameAs 1981507449 @default.
• W1981507449 citedByCount "8" @default.
• W1981507449 countsByYear W19815074492015 @default.
• W1981507449 countsByYear W19815074492016 @default.
• W1981507449 countsByYear W19815074492018 @default.
• W1981507449 countsByYear W19815074492023 @default.
• W1981507449 crossrefType "journal-article" @default.
• W1981507449 hasAuthorship W1981507449A5022600763 @default.
• W1981507449 hasAuthorship W1981507449A5023480923 @default.
• W1981507449 hasAuthorship W1981507449A5042559866 @default.
• W1981507449 hasAuthorship W1981507449A5052409368 @default.
• W1981507449 hasAuthorship W1981507449A5056125632 @default.
• W1981507449 hasAuthorship W1981507449A5056515301 @default.
• W1981507449 hasAuthorship W1981507449A5059911902 @default.
• W1981507449 hasAuthorship W1981507449A5063209025 @default.
• W1981507449 hasAuthorship W1981507449A5065783054 @default.
• W1981507449 hasAuthorship W1981507449A5076117140 @default.
• W1981507449 hasAuthorship W1981507449A5079410680 @default.
• W1981507449 hasAuthorship W1981507449A5084385524 @default.
• W1981507449 hasBestOaLocation W19815074491 @default.
• W1981507449 hasConcept C104317684 @default.
• W1981507449 hasConcept C107824862 @default.
• W1981507449 hasConcept C111368507 @default.
• W1981507449 hasConcept C125533998 @default.
• W1981507449 hasConcept C12554922 @default.
• W1981507449 hasConcept C127313418 @default.
• W1981507449 hasConcept C185592680 @default.
• W1981507449 hasConcept C2777028655 @default.
• W1981507449 hasConcept C2777400929 @default.
• W1981507449 hasConcept C547475151 @default.
• W1981507449 hasConcept C552990157 @default.
• W1981507449 hasConcept C55493867 @default.
• W1981507449 hasConcept C86803240 @default.
• W1981507449 hasConceptScore W1981507449C104317684 @default.

• next