FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981513751> ?p ?o ?g. }

• W1981513751 endingPage "694" @default.
• W1981513751 startingPage "683" @default.
• W1981513751 abstract "Increased prescribing of opioid analgesics for chronic noncancer pain may reflect acceptance that opioid benefits outweigh risks of adverse events for a broadening array of indications and patient populations; however, a parallel increase in the abuse, misuse, and diversion of prescription opioids has resulted. There is an urgent need to reduce opioid tampering and subsequent abuse without creating barriers to safe, effective analgesia. Similar to the “magic bullet” concept of antibiotic development (kill the bacteria without harming the patient), the idea behind reformulating opioid analgesics is to make them more difficult to tamper with and abuse by drug abusers but innocuous to the compliant patient. As antibiotics exploit differences in bacterial and human physiology, tamper-resistant formulations depend on differences in the way drug abusers and compliant patients consume opioids. Most opioid abusers tamper with tablets to facilitate oral, intranasal, or intravenous administration, whereas compliant patients usually take intact tablets. Pharmaceutical strategies to deter opioid abuse predominantly focus on tablet tampering, incorporating physical barriers (eg, crush resistance) or embedded chemicals that render tampered tablets inert, unusable, or noxious. Deterring tampering and abuse of intact tablets is more challenging. At present, only a few formulations with characteristics designed to oppose tampering for abuse have received approval by the US Food and Drug Administration, and none has been permitted to include claims of abuse deterrence or tamper resistance in their labeling. This review discusses the potential benefits, risks, and limitations associated with available tamper-resistant opioids and those in development." @default.
• W1981513751 created "2016-06-24" @default.
• W1981513751 creator A5006530314 @default.
• W1981513751 creator A5023955901 @default.
• W1981513751 creator A5030459129 @default.
• W1981513751 date "2012-07-01" @default.
• W1981513751 modified "2023-09-27" @default.
• W1981513751 title "Strategies to Reduce the Tampering and Subsequent Abuse of Long-acting Opioids: Potential Risks and Benefits of Formulations With Physical or Pharmacologic Deterrents to Tampering" @default.
• W1981513751 cites W1494229485 @default.
• W1981513751 cites W1970976350 @default.
• W1981513751 cites W1972589489 @default.
• W1981513751 cites W1972790570 @default.
• W1981513751 cites W1978872490 @default.
• W1981513751 cites W1978936941 @default.
• W1981513751 cites W1980398973 @default.
• W1981513751 cites W1984888219 @default.
• W1981513751 cites W1988117119 @default.
• W1981513751 cites W2005072029 @default.
• W1981513751 cites W2007742086 @default.
• W1981513751 cites W2017966774 @default.
• W1981513751 cites W2024012275 @default.
• W1981513751 cites W2024737247 @default.
• W1981513751 cites W2025749457 @default.
• W1981513751 cites W2030217998 @default.
• W1981513751 cites W2035572721 @default.
• W1981513751 cites W2038966872 @default.
• W1981513751 cites W2039385585 @default.
• W1981513751 cites W2044783221 @default.
• W1981513751 cites W2049608435 @default.
• W1981513751 cites W2051502497 @default.
• W1981513751 cites W2054285377 @default.
• W1981513751 cites W2057214026 @default.
• W1981513751 cites W2061720918 @default.
• W1981513751 cites W2070017645 @default.
• W1981513751 cites W2079126110 @default.
• W1981513751 cites W2082353968 @default.
• W1981513751 cites W2085074022 @default.
• W1981513751 cites W2085659851 @default.
• W1981513751 cites W2089911395 @default.
• W1981513751 cites W2090195992 @default.
• W1981513751 cites W2090562839 @default.
• W1981513751 cites W2104258796 @default.
• W1981513751 cites W2113651274 @default.
• W1981513751 cites W2117288913 @default.
• W1981513751 cites W2121587454 @default.
• W1981513751 cites W2131608328 @default.
• W1981513751 cites W2132989145 @default.
• W1981513751 cites W2136567229 @default.
• W1981513751 cites W2141882410 @default.
• W1981513751 cites W2145783290 @default.
• W1981513751 cites W2151608993 @default.
• W1981513751 cites W2163245621 @default.
• W1981513751 cites W2164671810 @default.
• W1981513751 cites W2167792025 @default.
• W1981513751 cites W2171114512 @default.
• W1981513751 cites W2304979503 @default.
• W1981513751 cites W2408612109 @default.
• W1981513751 cites W2747687728 @default.
• W1981513751 cites W3137367981 @default.
• W1981513751 cites W39085144 @default.
• W1981513751 cites W4242756503 @default.
• W1981513751 cites W4376595560 @default.
• W1981513751 cites W63482751 @default.
• W1981513751 cites W89030335 @default.
• W1981513751 doi "https://doi.org/10.1016/j.mayocp.2012.02.022" @default.
• W1981513751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3498428" @default.
• W1981513751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22766088" @default.
• W1981513751 hasPublicationYear "2012" @default.
• W1981513751 type Work @default.
• W1981513751 sameAs 1981513751 @default.
• W1981513751 citedByCount "73" @default.
• W1981513751 countsByYear W19815137512012 @default.
• W1981513751 countsByYear W19815137512013 @default.
• W1981513751 countsByYear W19815137512014 @default.
• W1981513751 countsByYear W19815137512015 @default.
• W1981513751 countsByYear W19815137512016 @default.
• W1981513751 countsByYear W19815137512017 @default.
• W1981513751 countsByYear W19815137512018 @default.
• W1981513751 countsByYear W19815137512019 @default.
• W1981513751 countsByYear W19815137512020 @default.
• W1981513751 countsByYear W19815137512022 @default.
• W1981513751 crossrefType "journal-article" @default.
• W1981513751 hasAuthorship W1981513751A5006530314 @default.
• W1981513751 hasAuthorship W1981513751A5023955901 @default.
• W1981513751 hasAuthorship W1981513751A5030459129 @default.
• W1981513751 hasBestOaLocation W19815137511 @default.
• W1981513751 hasConcept C118552586 @default.
• W1981513751 hasConcept C126322002 @default.
• W1981513751 hasConcept C170493617 @default.
• W1981513751 hasConcept C177713679 @default.
• W1981513751 hasConcept C2426938 @default.
• W1981513751 hasConcept C2777389121 @default.
• W1981513751 hasConcept C2778195246 @default.
• W1981513751 hasConcept C2781063702 @default.
• W1981513751 hasConcept C2781118164 @default.
• W1981513751 hasConcept C2992152733 @default.
• W1981513751 hasConcept C60644358 @default.
• W1981513751 hasConcept C71924100 @default.

• next