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• W1981532014 abstract "Background: Small leucine‐rich proteoglycans (SLRPs) decorin, biglycan, fibromodulin and lumican are secreted extracellular matrix molecules that associate with fibrillar collagens and regulate collagen fibrillogenesis. Collagens are the major extracellular matrix components of periodontal connective tissues where they provide mechanical attachment of the tooth to the bone and gingiva and mediate signals that regulate cell functions, including remodeling of the periodontal ligament and bone. Structural organization of collagen may also be important for the defense against periodontal disease, because in certain conditions abnormal collagen fibrils associate with increased susceptibility to periodontal disease. Objectives: The purpose of this study was to find out the role of SLRPs to regulate collagen fibril and fibril bundle formation in periodontal tissues. Methods: The localization of SLRPs in human and mouse periodontal tissues was studied using immunohistochemical methods. To assess the function of SLRPs we studied periodontal tissues of mice harboring targeted deletions of decorin, fibromodulin or lumican genes and lumican and fibromodulin double knockout mice using histological and electronmicroscopical methods. Results: The SLRPs were coexpressed in human and mouse gingival and periodontal ligament connective tissues where they colocalized with collagen fibril bundles. Teeth in the knockout animals were fully erupted and showed normal gross morphology. Targeted deletion of decorin, fibromodulin, lumican or both lumican and fibromodulin resulted in abnormal collagen fibril and fibril bundle morphology that was most evident in the periodontal ligament. Each of the gene deletions resulted in a unique fibril and fibril bundle phenotype. Conclusions: These findings indicate that decorin, fibromodulin and lumican coordinately regulate the fibrillar and suprafibrillar organization of collagen in the periodontal ligament." @default.
• W1981532014 created "2016-06-24" @default.
• W1981532014 creator A5057419396 @default.
• W1981532014 creator A5066095948 @default.
• W1981532014 creator A5088671321 @default.
• W1981532014 date "2005-06-20" @default.
• W1981532014 modified "2023-10-15" @default.
• W1981532014 title "Distinctive localization and function for lumican, fibromodulin and decorin to regulate collagen fibril organization in periodontal tissues" @default.
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• W1981532014 doi "https://doi.org/10.1111/j.1600-0765.2005.00800.x" @default.
• W1981532014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15966909" @default.
• W1981532014 hasPublicationYear "2005" @default.
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