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• W1981543101 abstract "Male Wistar rats were treated with L-3,5,3′-triiodothyronine (T 3 ) (500 μg∙kg∙ −1 ∙day −1 ) for 3 days. Cardiac sarcoplasmic reticulum (SR) was isolated at several time points during the induction of the hyperthyroid state and calcium transport and the levels of carnitine derivatives were determined. Calcium transport was augmented at all free calcium concentrations assayed (0.1–5.3 μM) 24 h following a single dose of T 3 ; at 48 and 72 h, calcium transport was further augmented. Calcium-dependent phosphoprotein levels were increased in the SR of the 48- and 72-h T 3 -treated groups. Total SR carnitine was reduced after 24, 48, and 72 h of treatment. Long chain acylcarnitine (LCAC) levels were decreased in T 3 -treated SR at 48 and 72 h. This study shows that calcium transport is increased in T 3 -treated rat heart SR and that this increase may be related to a reduction in the endogenous level of LCAC in the SR membrane." @default.
• W1981543101 created "2016-06-24" @default.
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• W1981543101 date "1988-02-01" @default.
• W1981543101 modified "2023-10-09" @default.
• W1981543101 title "Sarcoplasmic reticulum Ca²⁺ transport and long chain acylcarnitines in hyperthyroidism" @default.
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• W1981543101 doi "https://doi.org/10.1139/y88-028" @default.
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