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• W1981551140 abstract "Purpose To evaluate the long-term efficacy and safety of initial trabeculectomy with subconjunctival 5-fluorouracil in Japanese patients with primary open-angle glaucoma. Subjects and Methods Clinical records of 117 eyes from 117 patients with records of up to 14 years were retrospectively analyzed using the appropriate statistical methods. Results The mean follow-up period was 6.2 ± 3.6 years. Criteria for successful intraocular pressure control and success probability by Kaplan-Meier method at 12 years were intraocular pressure < 21 mm Hg without medication plus a 30% or more reduction in intraocular pressure, 50.4 ± 5.2% (SE) 38.2 ± 5.3%; and intraocular pressure < 16 mm Hg without medication plus a 30% or more reduction in intraocular pressure, 45.9 ± 5.1% (36.5 ± 5.2%). Cox multiple regression analysis showed that a younger age was associated with a higher success probability (P <0.01). Eyes with lower postoperative intraocular pressure tended to show more positive value of the MD slope (P = 0.0669), whereas 7% of successfully treated eyes showed a negative postoperative MD slope (P < 0.1). The probabilities for developing bleb leaks and bleb-related infections in eyes with a functioning bleb were 28.9 ± 12.5% and 13.0 ± 10.4% at 12 years. Conclusion Trabeculectomy with 5-fluorouracil as an initial surgery in Japanese patients with primary open-angle glaucoma was effective for long-term control of glaucoma. However, the probability of late-onset bleb-related complications was not low in eyes with a functioning bleb, stressing the importance of constant care regarding bleb status." @default.
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• W1981551140 date "2001-12-01" @default.
• W1981551140 modified "2023-09-23" @default.
• W1981551140 title "Long-term Follow-up of Initial 5-Fluorouracil Trabeculectomy in Primary Open-angle Glaucoma in Japanese Patients" @default.
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• W1981551140 doi "https://doi.org/10.1097/00061198-200112000-00004" @default.
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