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• W1981551145 abstract "1. The influence of environmental temperature on tissue levels of IGF-I mRNA and peptide has been investigated in 8 week old pigs living under conditions of controlled energy intake. Animals were acclimated to 35 or 10°C on a high (H) or low (L) energy intake (where H = 2L) and there were thus 4 treatment groups; 35H, 35L, 10H and 10L. 2. The warm temperature was associated with greater levels of IGF-I peptide in plasma and all tissues investigated (liver, kidney, skeletal muscle and heart). Temperature had significant but contrasting influences on IGF-I mRNA in liver and kidney: at 35 compared with 10°C, levels were increased in liver but reduced in kidney. Despite marked differences in growth and protein deposition, there was no effect of temperature on muscle IGF-I mRNA. 3. A high energy intake was associated with increased levels of IGF-I peptide in plasma and tissues. However, although there was a tendency for liver IGF-I mRNA to be elevated in the 35H compared with the 35L group, there was no overal effect of energy intake on IGF-I mRNA in any issue. 4. It is concluded that ambient temperature and energy intake can significantly affect the concentration of IGF-I peptide in tissues and that regulation may occur at either transcriptional or translational levels. The probability is that the effects of temperature are mediated via its infuence on energy balance." @default.
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• W1981551145 date "1992-03-01" @default.
• W1981551145 modified "2023-10-18" @default.
• W1981551145 title "Thermal and nutritional influences on tissue levels of insulin-like growth factor-I mRNA and peptide" @default.
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• W1981551145 doi "https://doi.org/10.1016/0306-4565(92)90004-y" @default.
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