FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981557788> ?p ?o ?g. }

• W1981557788 endingPage "431" @default.
• W1981557788 startingPage "424" @default.
• W1981557788 abstract "Paraoxonase (PON1) is an antioxidant enzyme that prevents LDL oxidation as well as detoxifies homocysteine thiolactone (HCTL), both of which can cause atherosclerosis. Chronic alcohol (ETOH) and high omega-3 polyunsaturated fatty acids (omega-3 PUFA) consumption may affect PON1 status presumably via reactive oxygen species by depleting liver glutathione (GSH), whereas betaine may counter their effects. Therefore, we investigated the influence of ETOH, omega-3 PUFA, and betaine on liver GSH, PON1 expression, lipid score, as well as serum PON1 and HCTLase activities.Experimental rats belonging to various dietary groups were pair-fed with Lieber-DeCarli low (2.8% the dietary calories as omega3-fatty acids) and high (13.8% the dietary calories as omega3-fatty acids) menhaden fish alcohol-liquid diets with and without betaine (10 g/l diet) for 8 weeks after which liver PON1 mRNA, GSH, lipid score, and serum PON1, HCTLase, and ALT activities were measured.High omega-3 PUFA decreased liver PON1 mRNA expression, serum PON1, and HCTLase activity by 23% (p < 0.01), 20% (p < 0.05), and 28% (p < 0.05), respectively compared to the low omega-3 PUFA group. ETOH decreased PON1 mRNA expression by 25 and 30% (p < 0.01) with concomitant 27% (p < 0.05) and 38% (p < 0.01), decrease in liver GSH levels in low and high omega-3 PUFA groups, respectively. Correspondingly, serum PON1 activity decreased by 23% (p < 0.05) and 58% (p < 0.01) while serum HCTLase activity decreased by 25% (p < 0.05) and 59% (p < 0.01) in the low and high omega-3 PUFA ETOH groups, respectively. Betaine restored liver PON1 mRNA expressions in low and high omega-3 PUFA ETOH groups with parallel restorations of PON1 activity and liver GSH. Concomitantly, betaine reduced hepatosteatosis accompanied by alleviation of liver injury caused by chronic alcohol and high omega-3 PUFA.Based on these results, we conclude that dietary betaine not only atheroprotective by restoring liver GSH that quenches free radicals, but also may alleviate liver injury by reducing hepatosteatosis." @default.
• W1981557788 created "2016-06-24" @default.
• W1981557788 creator A5020329562 @default.
• W1981557788 creator A5036170290 @default.
• W1981557788 creator A5058452861 @default.
• W1981557788 creator A5074664012 @default.
• W1981557788 creator A5086565161 @default.
• W1981557788 date "2010-03-01" @default.
• W1981557788 modified "2023-09-23" @default.
• W1981557788 title "Betaine Protects Chronic Alcohol and ω-3 PUFA-Mediated Down-Regulations of PON1 Gene, Serum PON1 and Homocysteine Thiolactonase Activities With Restoration of Liver GSH" @default.
• W1981557788 cites W1671050155 @default.
• W1981557788 cites W1827172940 @default.
• W1981557788 cites W1904575704 @default.
• W1981557788 cites W1956927897 @default.
• W1981557788 cites W1965188580 @default.
• W1981557788 cites W1975882704 @default.
• W1981557788 cites W2009469473 @default.
• W1981557788 cites W2021395497 @default.
• W1981557788 cites W2025679035 @default.
• W1981557788 cites W2034578182 @default.
• W1981557788 cites W2034711771 @default.
• W1981557788 cites W2055219529 @default.
• W1981557788 cites W2055459148 @default.
• W1981557788 cites W2061004057 @default.
• W1981557788 cites W2064929307 @default.
• W1981557788 cites W2072402720 @default.
• W1981557788 cites W2085098858 @default.
• W1981557788 cites W2086911626 @default.
• W1981557788 cites W2087736738 @default.
• W1981557788 cites W2090928890 @default.
• W1981557788 cites W2094245622 @default.
• W1981557788 cites W2094998344 @default.
• W1981557788 cites W2096419776 @default.
• W1981557788 cites W2096627428 @default.
• W1981557788 cites W2096664466 @default.
• W1981557788 cites W2102352450 @default.
• W1981557788 cites W2110118982 @default.
• W1981557788 cites W2123051564 @default.
• W1981557788 cites W2123799914 @default.
• W1981557788 cites W2128311759 @default.
• W1981557788 cites W2129454452 @default.
• W1981557788 cites W2133733927 @default.
• W1981557788 cites W2136561166 @default.
• W1981557788 cites W4240101191 @default.
• W1981557788 doi "https://doi.org/10.1111/j.1530-0277.2009.01107.x" @default.
• W1981557788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20028357" @default.
• W1981557788 hasPublicationYear "2010" @default.
• W1981557788 type Work @default.
• W1981557788 sameAs 1981557788 @default.
• W1981557788 citedByCount "29" @default.
• W1981557788 countsByYear W19815577882012 @default.
• W1981557788 countsByYear W19815577882013 @default.
• W1981557788 countsByYear W19815577882015 @default.
• W1981557788 countsByYear W19815577882016 @default.
• W1981557788 countsByYear W19815577882018 @default.
• W1981557788 countsByYear W19815577882019 @default.
• W1981557788 countsByYear W19815577882020 @default.
• W1981557788 countsByYear W19815577882023 @default.
• W1981557788 crossrefType "journal-article" @default.
• W1981557788 hasAuthorship W1981557788A5020329562 @default.
• W1981557788 hasAuthorship W1981557788A5036170290 @default.
• W1981557788 hasAuthorship W1981557788A5058452861 @default.
• W1981557788 hasAuthorship W1981557788A5074664012 @default.
• W1981557788 hasAuthorship W1981557788A5086565161 @default.
• W1981557788 hasConcept C104317684 @default.
• W1981557788 hasConcept C126322002 @default.
• W1981557788 hasConcept C134018914 @default.
• W1981557788 hasConcept C135763542 @default.
• W1981557788 hasConcept C181199279 @default.
• W1981557788 hasConcept C185592680 @default.
• W1981557788 hasConcept C19038510 @default.
• W1981557788 hasConcept C2776151105 @default.
• W1981557788 hasConcept C2776509667 @default.
• W1981557788 hasConcept C2777090595 @default.
• W1981557788 hasConcept C2777248517 @default.
• W1981557788 hasConcept C2780912031 @default.
• W1981557788 hasConcept C37501387 @default.
• W1981557788 hasConcept C515207424 @default.
• W1981557788 hasConcept C538909803 @default.
• W1981557788 hasConcept C543025807 @default.
• W1981557788 hasConcept C55493867 @default.
• W1981557788 hasConcept C71924100 @default.
• W1981557788 hasConcept C86803240 @default.
• W1981557788 hasConceptScore W1981557788C104317684 @default.
• W1981557788 hasConceptScore W1981557788C126322002 @default.
• W1981557788 hasConceptScore W1981557788C134018914 @default.
• W1981557788 hasConceptScore W1981557788C135763542 @default.
• W1981557788 hasConceptScore W1981557788C181199279 @default.
• W1981557788 hasConceptScore W1981557788C185592680 @default.
• W1981557788 hasConceptScore W1981557788C19038510 @default.
• W1981557788 hasConceptScore W1981557788C2776151105 @default.
• W1981557788 hasConceptScore W1981557788C2776509667 @default.
• W1981557788 hasConceptScore W1981557788C2777090595 @default.
• W1981557788 hasConceptScore W1981557788C2777248517 @default.
• W1981557788 hasConceptScore W1981557788C2780912031 @default.
• W1981557788 hasConceptScore W1981557788C37501387 @default.
• W1981557788 hasConceptScore W1981557788C515207424 @default.
• W1981557788 hasConceptScore W1981557788C538909803 @default.

• next