FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981566506> ?p ?o ?g. }

• W1981566506 endingPage "30104" @default.
• W1981566506 startingPage "30094" @default.
• W1981566506 abstract "Impairment of glucose-stimulated insulin secretion caused by the lipotoxicity of palmitate was found in β-cells. Recent studies have indicated that defects in autophagy contribute to pathogenesis in type 2 diabetes. Here, we report that autophagy-related 7 (Atg7) induced excessive autophagic activation in INS-1(823/13) cells exposed to saturated fatty acids. Atg7-induced cathepsin B (CTSB) overexpression resulted in an unexpected significant increase in proinflammatory chemokine and cytokine production levels of IL-1β, monocyte chemotactic protein-1, IL-6, and TNF-α. Inhibition of receptor-interacting protein did not affect the inflammatory response, ruling out involvement of necrosis. CTSB siRNA suppressed the inflammatory response but did not affect apoptosis significantly, suggesting that CTSB was a molecular linker between autophagy and the proinflammatory response. Blocking caspase-3 suppressed apoptosis but did not affect the inflammatory response, suggesting that CTSB induced inflammatory effects independently of apoptosis. Silencing of Nod-like receptor 3 (NLRP3) completely abolished both IL-1β secretion and the down-regulation effects of Atg7-induced CTSB overexpression on glucose-stimulated insulin secretion impairment, thus identifying the NLRP3 inflammasome as an autophagy-responsive element in the pancreatic INS-1(823/13) cell line. Combined together, our results indicate that CTSB contributed to the Atg7-induced NLRP3-dependent proinflammatory response, resulting in aggravation of lipotoxicity, independently of apoptosis in the pancreatic INS-1(823/13) cell line." @default.
• W1981566506 created "2016-06-24" @default.
• W1981566506 creator A5001184421 @default.
• W1981566506 creator A5013624090 @default.
• W1981566506 creator A5036740923 @default.
• W1981566506 creator A5044757881 @default.
• W1981566506 creator A5055411510 @default.
• W1981566506 creator A5065030665 @default.
• W1981566506 creator A5071369567 @default.
• W1981566506 creator A5072073221 @default.
• W1981566506 creator A5073597282 @default.
• W1981566506 creator A5079821375 @default.
• W1981566506 creator A5080985655 @default.
• W1981566506 date "2013-10-01" @default.
• W1981566506 modified "2023-10-13" @default.
• W1981566506 title "Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line" @default.
• W1981566506 cites W1946507092 @default.
• W1981566506 cites W1968881408 @default.
• W1981566506 cites W1970303002 @default.
• W1981566506 cites W1972336737 @default.
• W1981566506 cites W1973472942 @default.
• W1981566506 cites W1977767269 @default.
• W1981566506 cites W1985538633 @default.
• W1981566506 cites W1992012350 @default.
• W1981566506 cites W2014700733 @default.
• W1981566506 cites W2017614405 @default.
• W1981566506 cites W2019698047 @default.
• W1981566506 cites W2020468088 @default.
• W1981566506 cites W2024951795 @default.
• W1981566506 cites W2028545985 @default.
• W1981566506 cites W2030287946 @default.
• W1981566506 cites W2034946303 @default.
• W1981566506 cites W2043143751 @default.
• W1981566506 cites W2051303794 @default.
• W1981566506 cites W2063932784 @default.
• W1981566506 cites W2064741210 @default.
• W1981566506 cites W2071573974 @default.
• W1981566506 cites W2079608589 @default.
• W1981566506 cites W2081361522 @default.
• W1981566506 cites W2099304566 @default.
• W1981566506 cites W2099360283 @default.
• W1981566506 cites W2109070574 @default.
• W1981566506 cites W2113010696 @default.
• W1981566506 cites W2118403357 @default.
• W1981566506 cites W2121875511 @default.
• W1981566506 cites W2125738477 @default.
• W1981566506 cites W2126610675 @default.
• W1981566506 cites W2130495917 @default.
• W1981566506 cites W2133586331 @default.
• W1981566506 cites W2137334382 @default.
• W1981566506 cites W2139203772 @default.
• W1981566506 cites W2145206598 @default.
• W1981566506 cites W2150367899 @default.
• W1981566506 cites W2170536105 @default.
• W1981566506 doi "https://doi.org/10.1074/jbc.m113.494286" @default.
• W1981566506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3798478" @default.
• W1981566506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23986436" @default.
• W1981566506 hasPublicationYear "2013" @default.
• W1981566506 type Work @default.
• W1981566506 sameAs 1981566506 @default.
• W1981566506 citedByCount "46" @default.
• W1981566506 countsByYear W19815665062014 @default.
• W1981566506 countsByYear W19815665062015 @default.
• W1981566506 countsByYear W19815665062016 @default.
• W1981566506 countsByYear W19815665062017 @default.
• W1981566506 countsByYear W19815665062018 @default.
• W1981566506 countsByYear W19815665062019 @default.
• W1981566506 countsByYear W19815665062020 @default.
• W1981566506 countsByYear W19815665062021 @default.
• W1981566506 countsByYear W19815665062022 @default.
• W1981566506 countsByYear W19815665062023 @default.
• W1981566506 crossrefType "journal-article" @default.
• W1981566506 hasAuthorship W1981566506A5001184421 @default.
• W1981566506 hasAuthorship W1981566506A5013624090 @default.
• W1981566506 hasAuthorship W1981566506A5036740923 @default.
• W1981566506 hasAuthorship W1981566506A5044757881 @default.
• W1981566506 hasAuthorship W1981566506A5055411510 @default.
• W1981566506 hasAuthorship W1981566506A5065030665 @default.
• W1981566506 hasAuthorship W1981566506A5071369567 @default.
• W1981566506 hasAuthorship W1981566506A5072073221 @default.
• W1981566506 hasAuthorship W1981566506A5073597282 @default.
• W1981566506 hasAuthorship W1981566506A5079821375 @default.
• W1981566506 hasAuthorship W1981566506A5080985655 @default.
• W1981566506 hasBestOaLocation W19815665061 @default.
• W1981566506 hasConcept C126322002 @default.
• W1981566506 hasConcept C134018914 @default.
• W1981566506 hasConcept C164027704 @default.
• W1981566506 hasConcept C17172800 @default.
• W1981566506 hasConcept C181199279 @default.
• W1981566506 hasConcept C185592680 @default.
• W1981566506 hasConcept C190283241 @default.
• W1981566506 hasConcept C203014093 @default.
• W1981566506 hasConcept C203522944 @default.
• W1981566506 hasConcept C2776914184 @default.
• W1981566506 hasConcept C2777209026 @default.
• W1981566506 hasConcept C2777391703 @default.
• W1981566506 hasConcept C2779306644 @default.
• W1981566506 hasConcept C28021979 @default.

• next