FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981567186> ?p ?o ?g. }

• W1981567186 endingPage "204" @default.
• W1981567186 startingPage "200" @default.
• W1981567186 abstract "Withdrawal of differentiating cells from proliferative tissue is critical for embryonic development and adult tissue homeostasis; however, the mechanisms that control this cell behavior are poorly understood. Using high-resolution live-cell imaging in chick neural tube, we uncover a form of cell subdivision that abscises apical cell membrane and mediates neuron detachment from the ventricle. This mechanism operates in chick and mouse, is dependent on actin-myosin contraction, and results in loss of apical cell polarity. Apical abscission also dismantles the primary cilium, known to transduce sonic-hedgehog signals, and is required for expression of cell-cycle-exit gene p27/Kip1. We further show that N-cadherin levels, regulated by neuronal-differentiation factor Neurog2, determine cilium disassembly and final abscission. This cell-biological mechanism may mediate such cell transitions in other epithelia in normal and cancerous conditions." @default.
• W1981567186 created "2016-06-24" @default.
• W1981567186 creator A5000988484 @default.
• W1981567186 creator A5081416045 @default.
• W1981567186 date "2014-01-10" @default.
• W1981567186 modified "2023-10-10" @default.
• W1981567186 title "Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis" @default.
• W1981567186 cites W1498131948 @default.
• W1981567186 cites W1966888972 @default.
• W1981567186 cites W1974781839 @default.
• W1981567186 cites W1977282931 @default.
• W1981567186 cites W1981697546 @default.
• W1981567186 cites W2001372249 @default.
• W1981567186 cites W2001574193 @default.
• W1981567186 cites W2008578910 @default.
• W1981567186 cites W2009582775 @default.
• W1981567186 cites W2012535690 @default.
• W1981567186 cites W2015023335 @default.
• W1981567186 cites W2027936687 @default.
• W1981567186 cites W2032792789 @default.
• W1981567186 cites W2039614478 @default.
• W1981567186 cites W2043655216 @default.
• W1981567186 cites W2059155214 @default.
• W1981567186 cites W2083363004 @default.
• W1981567186 cites W2107885943 @default.
• W1981567186 cites W2111761019 @default.
• W1981567186 cites W2114882581 @default.
• W1981567186 cites W2126771830 @default.
• W1981567186 cites W2127220436 @default.
• W1981567186 cites W2143339100 @default.
• W1981567186 cites W2143826692 @default.
• W1981567186 cites W2145489844 @default.
• W1981567186 cites W2151447171 @default.
• W1981567186 cites W2160084509 @default.
• W1981567186 cites W4211047249 @default.
• W1981567186 doi "https://doi.org/10.1126/science.1247521" @default.
• W1981567186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4066580" @default.
• W1981567186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24408437" @default.
• W1981567186 hasPublicationYear "2014" @default.
• W1981567186 type Work @default.
• W1981567186 sameAs 1981567186 @default.
• W1981567186 citedByCount "147" @default.
• W1981567186 countsByYear W19815671862014 @default.
• W1981567186 countsByYear W19815671862015 @default.
• W1981567186 countsByYear W19815671862016 @default.
• W1981567186 countsByYear W19815671862017 @default.
• W1981567186 countsByYear W19815671862018 @default.
• W1981567186 countsByYear W19815671862019 @default.
• W1981567186 countsByYear W19815671862020 @default.
• W1981567186 countsByYear W19815671862021 @default.
• W1981567186 countsByYear W19815671862022 @default.
• W1981567186 countsByYear W19815671862023 @default.
• W1981567186 crossrefType "journal-article" @default.
• W1981567186 hasAuthorship W1981567186A5000988484 @default.
• W1981567186 hasAuthorship W1981567186A5081416045 @default.
• W1981567186 hasBestOaLocation W19815671862 @default.
• W1981567186 hasConcept C100094513 @default.
• W1981567186 hasConcept C104317684 @default.
• W1981567186 hasConcept C145103041 @default.
• W1981567186 hasConcept C1491633281 @default.
• W1981567186 hasConcept C168240541 @default.
• W1981567186 hasConcept C176080148 @default.
• W1981567186 hasConcept C2776878037 @default.
• W1981567186 hasConcept C2778539099 @default.
• W1981567186 hasConcept C39579648 @default.
• W1981567186 hasConcept C40692019 @default.
• W1981567186 hasConcept C4746552 @default.
• W1981567186 hasConcept C49353375 @default.
• W1981567186 hasConcept C54355233 @default.
• W1981567186 hasConcept C62478195 @default.
• W1981567186 hasConcept C86803240 @default.
• W1981567186 hasConcept C95444343 @default.
• W1981567186 hasConceptScore W1981567186C100094513 @default.
• W1981567186 hasConceptScore W1981567186C104317684 @default.
• W1981567186 hasConceptScore W1981567186C145103041 @default.
• W1981567186 hasConceptScore W1981567186C1491633281 @default.
• W1981567186 hasConceptScore W1981567186C168240541 @default.
• W1981567186 hasConceptScore W1981567186C176080148 @default.
• W1981567186 hasConceptScore W1981567186C2776878037 @default.
• W1981567186 hasConceptScore W1981567186C2778539099 @default.
• W1981567186 hasConceptScore W1981567186C39579648 @default.
• W1981567186 hasConceptScore W1981567186C40692019 @default.
• W1981567186 hasConceptScore W1981567186C4746552 @default.
• W1981567186 hasConceptScore W1981567186C49353375 @default.
• W1981567186 hasConceptScore W1981567186C54355233 @default.
• W1981567186 hasConceptScore W1981567186C62478195 @default.
• W1981567186 hasConceptScore W1981567186C86803240 @default.
• W1981567186 hasConceptScore W1981567186C95444343 @default.
• W1981567186 hasIssue "6167" @default.
• W1981567186 hasLocation W19815671861 @default.
• W1981567186 hasLocation W19815671862 @default.
• W1981567186 hasLocation W19815671863 @default.
• W1981567186 hasLocation W19815671864 @default.
• W1981567186 hasOpenAccess W1981567186 @default.
• W1981567186 hasPrimaryLocation W19815671861 @default.
• W1981567186 hasRelatedWork W1486014738 @default.
• W1981567186 hasRelatedWork W1968687490 @default.
• W1981567186 hasRelatedWork W1968981755 @default.

• next