FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981574243> ?p ?o ?g. }

• W1981574243 endingPage "1219" @default.
• W1981574243 startingPage "1210" @default.
• W1981574243 abstract "Diltiazem may provide a protective effect to ischemic and reperfused myocardium through preservation of high-energy phosphate metabolism. To test this hypothesis, rabbits had a 1.3 cm solenoidal coil placed over the myocardium to be rendered ischemic. Data were acquired with a 22 cm bore nuclear magnetic resonance spectrometer at 2.0 T. Animals were treated with diltiazem (200 μg/kg intravenous bolus of drug followed by a 15 μg/kg/min continuous intravenous infusion, n = 10) or by an equal volume of saline (n = 6). The left circumflex artery was occluded and reperfused using a reversible snare while electrocardiogram-gated spectra were accumulated. Levels of phosphocreatine were decreased during occlusion in both groups; however, this decrease was attenuated in the diltiazem treated animals compared to control (in relative percent area: 7.8 ± 1.0 to 2.5 ± 0.5, p < 0.01). Levels of phosphocreatine promptly returned to baseline following reperfusion and there was no difference between the two groups. The inorganic phosphate metabolites of high-energy phosphate consumption increased with occlusion, though more so in the control group compared with the diltiazem-treated rabbits (in relative percent area: 72.5 ± 0.9 to 55.4 ± 1.3, p < 0.01). With reperfusion, levels of inorganic phosphates returned toward baseline in both groups; however, the diltiazem group had a more complete recovery relative to control (in relative percent area: 38.8 ± 2.1 to 47.6 ± 2.7, p < 0.05). Levels of adenosine triphosphate decreased in both groups relative to baseline; however, the amount of decrease was similar in the two groups. With reperfusion there was a definite though incomplete recovery of levels of adenosine triphosphate in the diltiazem-treated group (in relative percent area: 10.7 ± 1.0 at occlusion, 12.3 ± 0.4 during reperfusion, p < 0.05), but in the control group levels of adenosine triphosphate remained depressed (in relative percent area: 9.8 ± 0.6 at occlusion, 9.8 ± 0.8 during reperfusion, p = NS). During ischemia there was a trend toward attenuation of intracellular acidosis in the diltiazem group; however, this trend did not reach statistical significance. These data indicate that diltiazem provides a protective effect on myocardial high-energy phosphate metabolism during regional ischemia and reperfusion in the intact animal." @default.
• W1981574243 created "2016-06-24" @default.
• W1981574243 creator A5007789760 @default.
• W1981574243 creator A5011266478 @default.
• W1981574243 creator A5021662958 @default.
• W1981574243 creator A5059500199 @default.
• W1981574243 creator A5069844604 @default.
• W1981574243 creator A5086298498 @default.
• W1981574243 date "1989-12-01" @default.
• W1981574243 modified "2023-09-26" @default.
• W1981574243 title "Effects of diltiazem on phosphate metabolism in ischemic and reperfused myocardium using phosphorus31 nuclear magnetic resonance spectroscopy in vivo" @default.
• W1981574243 cites W1535759476 @default.
• W1981574243 cites W1840325563 @default.
• W1981574243 cites W1965127241 @default.
• W1981574243 cites W1965584174 @default.
• W1981574243 cites W1965951694 @default.
• W1981574243 cites W1981531583 @default.
• W1981574243 cites W1984876837 @default.
• W1981574243 cites W1986642034 @default.
• W1981574243 cites W1993245379 @default.
• W1981574243 cites W1998104311 @default.
• W1981574243 cites W1999761427 @default.
• W1981574243 cites W2001970687 @default.
• W1981574243 cites W2015490983 @default.
• W1981574243 cites W2018068332 @default.
• W1981574243 cites W2019954751 @default.
• W1981574243 cites W2056554737 @default.
• W1981574243 cites W2067249646 @default.
• W1981574243 cites W2071188583 @default.
• W1981574243 cites W2077079076 @default.
• W1981574243 cites W2078044981 @default.
• W1981574243 cites W2090261125 @default.
• W1981574243 cites W2094097240 @default.
• W1981574243 cites W2102896366 @default.
• W1981574243 cites W2106896207 @default.
• W1981574243 cites W2117594247 @default.
• W1981574243 cites W2133680772 @default.
• W1981574243 cites W2173520866 @default.
• W1981574243 doi "https://doi.org/10.1016/0002-8703(89)90012-4" @default.
• W1981574243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2589162" @default.
• W1981574243 hasPublicationYear "1989" @default.
• W1981574243 type Work @default.
• W1981574243 sameAs 1981574243 @default.
• W1981574243 citedByCount "8" @default.
• W1981574243 countsByYear W19815742432022 @default.
• W1981574243 countsByYear W19815742432023 @default.
• W1981574243 crossrefType "journal-article" @default.
• W1981574243 hasAuthorship W1981574243A5007789760 @default.
• W1981574243 hasAuthorship W1981574243A5011266478 @default.
• W1981574243 hasAuthorship W1981574243A5021662958 @default.
• W1981574243 hasAuthorship W1981574243A5059500199 @default.
• W1981574243 hasAuthorship W1981574243A5069844604 @default.
• W1981574243 hasAuthorship W1981574243A5086298498 @default.
• W1981574243 hasBestOaLocation W19815742432 @default.
• W1981574243 hasConcept C126322002 @default.
• W1981574243 hasConcept C164705383 @default.
• W1981574243 hasConcept C2776741139 @default.
• W1981574243 hasConcept C2777397205 @default.
• W1981574243 hasConcept C2778273184 @default.
• W1981574243 hasConcept C2778626300 @default.
• W1981574243 hasConcept C2986317502 @default.
• W1981574243 hasConcept C2989005 @default.
• W1981574243 hasConcept C42219234 @default.
• W1981574243 hasConcept C519063684 @default.
• W1981574243 hasConcept C541997718 @default.
• W1981574243 hasConcept C71924100 @default.
• W1981574243 hasConceptScore W1981574243C126322002 @default.
• W1981574243 hasConceptScore W1981574243C164705383 @default.
• W1981574243 hasConceptScore W1981574243C2776741139 @default.
• W1981574243 hasConceptScore W1981574243C2777397205 @default.
• W1981574243 hasConceptScore W1981574243C2778273184 @default.
• W1981574243 hasConceptScore W1981574243C2778626300 @default.
• W1981574243 hasConceptScore W1981574243C2986317502 @default.
• W1981574243 hasConceptScore W1981574243C2989005 @default.
• W1981574243 hasConceptScore W1981574243C42219234 @default.
• W1981574243 hasConceptScore W1981574243C519063684 @default.
• W1981574243 hasConceptScore W1981574243C541997718 @default.
• W1981574243 hasConceptScore W1981574243C71924100 @default.
• W1981574243 hasIssue "6" @default.
• W1981574243 hasLocation W19815742431 @default.
• W1981574243 hasLocation W19815742432 @default.
• W1981574243 hasLocation W19815742433 @default.
• W1981574243 hasOpenAccess W1981574243 @default.
• W1981574243 hasPrimaryLocation W19815742431 @default.
• W1981574243 hasRelatedWork W1970946879 @default.
• W1981574243 hasRelatedWork W1976830811 @default.
• W1981574243 hasRelatedWork W1981574243 @default.
• W1981574243 hasRelatedWork W2025886151 @default.
• W1981574243 hasRelatedWork W2041997932 @default.
• W1981574243 hasRelatedWork W2063563825 @default.
• W1981574243 hasRelatedWork W2104801094 @default.
• W1981574243 hasRelatedWork W2121416425 @default.
• W1981574243 hasRelatedWork W3148991104 @default.
• W1981574243 hasRelatedWork W3149088047 @default.
• W1981574243 hasVolume "118" @default.
• W1981574243 isParatext "false" @default.
• W1981574243 isRetracted "false" @default.
• W1981574243 magId "1981574243" @default.

• next