Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981584098> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1981584098 endingPage "271" @default.
- W1981584098 startingPage "265" @default.
- W1981584098 abstract "In our study, we have screened 133 structurally diverse natural compounds from the MEGx® collection of AnalytiCon Discovery and three synthetic hispolone analogs for binding affinity to Plasmodium falciparum thioredoxin reductase (PfTrxR) using an ultrafiltration (UF) and liquid chromatography (LC/MS) based ligand-binding assay newly developed in our laboratory. PfTrxR catalyzes the reduction of thioredoxin (PfTrx) protein. In reduced form, PfTrx is essentially involved in the antioxidative defense and redox regulation of P. falciparum. Nine compounds (yohimbine (1), catharanthine (2), vobasine (3), gnetifolin E (4), quinidine N-oxide (5), 11-hydroxycoronaridine (6), hispolone (7), hispolone methyl ether (8), and hernagine (9)) displayed binding affinity for PfTrxR at 1 μM. The ranking order of compound's binding affinities for PfTrxR is 7 > 6 > 2 > 4 > 5 > 8 > 1 > 9 > 3. On the other hand, compounds 6, 7, 2 and 8 demonstrated specific binding to the active site of PfTrxR, when ligands were tested in an equimolar mixture of 1 μM." @default.
- W1981584098 created "2016-06-24" @default.
- W1981584098 creator A5025125373 @default.
- W1981584098 creator A5025778098 @default.
- W1981584098 creator A5085021352 @default.
- W1981584098 date "2011-05-01" @default.
- W1981584098 modified "2023-10-14" @default.
- W1981584098 title "Screening of natural compounds for ligands to PfTrxR by ultrafiltration and LC–MS based binding assay" @default.
- W1981584098 cites W1964703598 @default.
- W1981584098 cites W1966500220 @default.
- W1981584098 cites W1981614245 @default.
- W1981584098 cites W1981743332 @default.
- W1981584098 cites W1984167828 @default.
- W1981584098 cites W1984566244 @default.
- W1981584098 cites W1987666508 @default.
- W1981584098 cites W2011754188 @default.
- W1981584098 cites W2018526147 @default.
- W1981584098 cites W2021009957 @default.
- W1981584098 cites W2027499489 @default.
- W1981584098 cites W2034370520 @default.
- W1981584098 cites W2038522569 @default.
- W1981584098 cites W2044958019 @default.
- W1981584098 cites W2061072273 @default.
- W1981584098 cites W2090638399 @default.
- W1981584098 cites W2115600413 @default.
- W1981584098 cites W2116919367 @default.
- W1981584098 cites W2156917393 @default.
- W1981584098 cites W4293247451 @default.
- W1981584098 doi "https://doi.org/10.1016/j.jpba.2011.01.033" @default.
- W1981584098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21353756" @default.
- W1981584098 hasPublicationYear "2011" @default.
- W1981584098 type Work @default.
- W1981584098 sameAs 1981584098 @default.
- W1981584098 citedByCount "29" @default.
- W1981584098 countsByYear W19815840982012 @default.
- W1981584098 countsByYear W19815840982013 @default.
- W1981584098 countsByYear W19815840982014 @default.
- W1981584098 countsByYear W19815840982015 @default.
- W1981584098 countsByYear W19815840982016 @default.
- W1981584098 countsByYear W19815840982017 @default.
- W1981584098 countsByYear W19815840982018 @default.
- W1981584098 countsByYear W19815840982019 @default.
- W1981584098 countsByYear W19815840982020 @default.
- W1981584098 countsByYear W19815840982021 @default.
- W1981584098 countsByYear W19815840982022 @default.
- W1981584098 countsByYear W19815840982023 @default.
- W1981584098 crossrefType "journal-article" @default.
- W1981584098 hasAuthorship W1981584098A5025125373 @default.
- W1981584098 hasAuthorship W1981584098A5025778098 @default.
- W1981584098 hasAuthorship W1981584098A5085021352 @default.
- W1981584098 hasConcept C107824862 @default.
- W1981584098 hasConcept C116569031 @default.
- W1981584098 hasConcept C170493617 @default.
- W1981584098 hasConcept C178790620 @default.
- W1981584098 hasConcept C179247698 @default.
- W1981584098 hasConcept C181199279 @default.
- W1981584098 hasConcept C185592680 @default.
- W1981584098 hasConcept C2780407432 @default.
- W1981584098 hasConcept C3018795828 @default.
- W1981584098 hasConcept C43617362 @default.
- W1981584098 hasConcept C50817676 @default.
- W1981584098 hasConcept C55493867 @default.
- W1981584098 hasConcept C71240020 @default.
- W1981584098 hasConcept C85196483 @default.
- W1981584098 hasConceptScore W1981584098C107824862 @default.
- W1981584098 hasConceptScore W1981584098C116569031 @default.
- W1981584098 hasConceptScore W1981584098C170493617 @default.
- W1981584098 hasConceptScore W1981584098C178790620 @default.
- W1981584098 hasConceptScore W1981584098C179247698 @default.
- W1981584098 hasConceptScore W1981584098C181199279 @default.
- W1981584098 hasConceptScore W1981584098C185592680 @default.
- W1981584098 hasConceptScore W1981584098C2780407432 @default.
- W1981584098 hasConceptScore W1981584098C3018795828 @default.
- W1981584098 hasConceptScore W1981584098C43617362 @default.
- W1981584098 hasConceptScore W1981584098C50817676 @default.
- W1981584098 hasConceptScore W1981584098C55493867 @default.
- W1981584098 hasConceptScore W1981584098C71240020 @default.
- W1981584098 hasConceptScore W1981584098C85196483 @default.
- W1981584098 hasIssue "2" @default.
- W1981584098 hasLocation W19815840981 @default.
- W1981584098 hasLocation W19815840982 @default.
- W1981584098 hasOpenAccess W1981584098 @default.
- W1981584098 hasPrimaryLocation W19815840981 @default.
- W1981584098 hasRelatedWork W120149818 @default.
- W1981584098 hasRelatedWork W1966342524 @default.
- W1981584098 hasRelatedWork W1981584098 @default.
- W1981584098 hasRelatedWork W2025584407 @default.
- W1981584098 hasRelatedWork W2038956339 @default.
- W1981584098 hasRelatedWork W2054105095 @default.
- W1981584098 hasRelatedWork W2075924119 @default.
- W1981584098 hasRelatedWork W2411964334 @default.
- W1981584098 hasRelatedWork W3113058943 @default.
- W1981584098 hasRelatedWork W2810749946 @default.
- W1981584098 hasVolume "55" @default.
- W1981584098 isParatext "false" @default.
- W1981584098 isRetracted "false" @default.
- W1981584098 magId "1981584098" @default.
- W1981584098 workType "article" @default.