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- W1981589204 abstract "Albumin is organized in three homologous domains formed by double loops stabilized by disulfide bonds. Utilizing a secretory expression system based on a synthetic secretory prepro-leader, the three human serum albumin domains were expressed in the yeastSaccharomyces cerevisiae.Human serum albumin domains I and III were efficiently expressed and secreted, indicating that these domains can form independent structural units capable of folding into stable tertiary structures. In contrast, albumin domain II was not secreted and disappeared early in the secretory pathway. Human serum albumin has the ability to bind a large number of small molecule ligands, including fatty acids, presumably due to its structure and structural flexibility. Purified albumin domain III bound myristic acid, whereas purified albumin domain I did not bind myristic acid. A new soluble long-acting insulin an alogue acylated with myristic acid (Markussen J.,et al., Diabetologia39, 281–288, 1996) bound to domain III and bound markedly more weakly to domain I." @default.
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- W1981589204 date "1998-07-01" @default.
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- W1981589204 title "Secretory Expression of Human Albumin Domains inSaccharomyces cerevisiaeand Their Binding of Myristic Acid and an Acylated Insulin Analogue" @default.
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- W1981589204 doi "https://doi.org/10.1006/prep.1998.0876" @default.
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