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• W1981605618 abstract "We have investigated the correlation between functional and morphological deficits in PMN mice, an animal model of human motoneuron disease. Electrophysiologic investigations showed first abnormalities, i.e. reduction of M-response amplitudes, already at postnatal d 13 when the disease was not yet phenotypically apparent, and when motoneuron and motor axon numbers were still normal. After d 27, a loss of more than 30% of motoneuron axons and cell bodies was detectable in the phrenic nerve and facial nucleus, respectively. At that stage, PMN mice showed severe functional and electrophysiological deficits. At later stages of the disease when still more than 50% of motor axons and at least 60% of motoneuron cell bodies were present, the distal compound muscle action potential amplitude decreased by more than 95% in small foot muscles after sciatic nerve stimulation. We conclude that functional deficits precede structural deficits in this animal model of human motoneuron disease. Our findings are in agreement with the concept of the 'sick motoneuron' in this animal model of motoneuron disease rather than the idea of progressive loss of motoneurons resulting in disease only after a significant number of motoneurons has degenerated." @default.
• W1981605618 created "2016-06-24" @default.
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• W1981605618 date "1999-10-01" @default.
• W1981605618 modified "2023-09-26" @default.
• W1981605618 title "Comparative analysis of motoneuron loss and functional deficits in PMN mice: implications for human motoneuron disease" @default.
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• W1981605618 doi "https://doi.org/10.1016/s0022-510x(99)00237-3" @default.
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