FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981631242> ?p ?o ?g. }

• W1981631242 endingPage "220" @default.
• W1981631242 startingPage "211" @default.
• W1981631242 abstract "Calcineurin subunit isoforms are implicated in long term potentiation, long term depression, and structural plasticity. Calcineurin inhibitors benefit axonal damage, cellular dysfunction, and cognitive outcomes in animal models of traumatic brain injury (TBI). Distribution of the catalytic calcineurin A subunit is altered and calcineurin activity increased following fluid percussion injury. Alterations in calcineurin subunit A isoform distribution within the hippocampus also occur post controlled cortical impact (CCI) demonstrating a reduction in catalytic subunit distribution in CA1-2 dendritic fields. Furthermore the effect of TBI on the regulatory subunit, calcineurin B, is unknown. Understanding the role of both subunits is necessary to effectively target alterations in calcineurin signaling as current calcineurin inhibitors, such as cyclosporin A and FK-506, rely upon binding sites on both subunits for complete inhibition. The effect of moderate CCI on the expression and distribution of calcineurin B isoforms within the hippocampus was examined at 2h and 2weeks post injury. Calcineurin B isoforms showed increased expression throughout the CA1 and CA2 while there was a decrease in expression within the ipsilateral dentate gyrus. Alterations in CnB isoform expression within the CA1, CA1-2, and dentate gyrus have significant implications for persistent hippocampal dysfunction following TBI. Regional changes in regulatory subunit expression may alter the effect of calcineurin inhibitors regionally following a traumatic brain injury." @default.
• W1981631242 created "2016-06-24" @default.
• W1981631242 creator A5018477607 @default.
• W1981631242 creator A5022154207 @default.
• W1981631242 creator A5043326654 @default.
• W1981631242 creator A5043417291 @default.
• W1981631242 creator A5051374100 @default.
• W1981631242 date "2010-10-01" @default.
• W1981631242 modified "2023-10-17" @default.
• W1981631242 title "Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury" @default.
• W1981631242 cites W1489781825 @default.
• W1981631242 cites W1528505919 @default.
• W1981631242 cites W1796802340 @default.
• W1981631242 cites W1963956528 @default.
• W1981631242 cites W1970958924 @default.
• W1981631242 cites W1985235409 @default.
• W1981631242 cites W1989824843 @default.
• W1981631242 cites W2000620316 @default.
• W1981631242 cites W2006459253 @default.
• W1981631242 cites W2011348649 @default.
• W1981631242 cites W2027105301 @default.
• W1981631242 cites W2027110425 @default.
• W1981631242 cites W2030661199 @default.
• W1981631242 cites W2036316405 @default.
• W1981631242 cites W2039471102 @default.
• W1981631242 cites W2040232914 @default.
• W1981631242 cites W2042203151 @default.
• W1981631242 cites W2043095820 @default.
• W1981631242 cites W2043100717 @default.
• W1981631242 cites W2054678898 @default.
• W1981631242 cites W2055981915 @default.
• W1981631242 cites W2067629356 @default.
• W1981631242 cites W2079311079 @default.
• W1981631242 cites W2080155879 @default.
• W1981631242 cites W2080169144 @default.
• W1981631242 cites W2090265903 @default.
• W1981631242 cites W2093948248 @default.
• W1981631242 cites W2102256305 @default.
• W1981631242 cites W2143302994 @default.
• W1981631242 cites W2172196619 @default.
• W1981631242 cites W2469974450 @default.
• W1981631242 doi "https://doi.org/10.1016/j.brainres.2010.08.029" @default.
• W1981631242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2949526" @default.
• W1981631242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20713027" @default.
• W1981631242 hasPublicationYear "2010" @default.
• W1981631242 type Work @default.
• W1981631242 sameAs 1981631242 @default.
• W1981631242 citedByCount "12" @default.
• W1981631242 countsByYear W19816312422012 @default.
• W1981631242 countsByYear W19816312422013 @default.
• W1981631242 countsByYear W19816312422014 @default.
• W1981631242 countsByYear W19816312422015 @default.
• W1981631242 countsByYear W19816312422017 @default.
• W1981631242 countsByYear W19816312422021 @default.
• W1981631242 countsByYear W19816312422023 @default.
• W1981631242 crossrefType "journal-article" @default.
• W1981631242 hasAuthorship W1981631242A5018477607 @default.
• W1981631242 hasAuthorship W1981631242A5022154207 @default.
• W1981631242 hasAuthorship W1981631242A5043326654 @default.
• W1981631242 hasAuthorship W1981631242A5043417291 @default.
• W1981631242 hasAuthorship W1981631242A5051374100 @default.
• W1981631242 hasBestOaLocation W19816312422 @default.
• W1981631242 hasConcept C104292427 @default.
• W1981631242 hasConcept C104317684 @default.
• W1981631242 hasConcept C126322002 @default.
• W1981631242 hasConcept C128057223 @default.
• W1981631242 hasConcept C134018914 @default.
• W1981631242 hasConcept C148762608 @default.
• W1981631242 hasConcept C169760540 @default.
• W1981631242 hasConcept C170493617 @default.
• W1981631242 hasConcept C25274449 @default.
• W1981631242 hasConcept C2776464000 @default.
• W1981631242 hasConcept C2781161787 @default.
• W1981631242 hasConcept C2911091166 @default.
• W1981631242 hasConcept C53345823 @default.
• W1981631242 hasConcept C55493867 @default.
• W1981631242 hasConcept C71924100 @default.
• W1981631242 hasConcept C86803240 @default.
• W1981631242 hasConceptScore W1981631242C104292427 @default.
• W1981631242 hasConceptScore W1981631242C104317684 @default.
• W1981631242 hasConceptScore W1981631242C126322002 @default.
• W1981631242 hasConceptScore W1981631242C128057223 @default.
• W1981631242 hasConceptScore W1981631242C134018914 @default.
• W1981631242 hasConceptScore W1981631242C148762608 @default.
• W1981631242 hasConceptScore W1981631242C169760540 @default.
• W1981631242 hasConceptScore W1981631242C170493617 @default.
• W1981631242 hasConceptScore W1981631242C25274449 @default.
• W1981631242 hasConceptScore W1981631242C2776464000 @default.
• W1981631242 hasConceptScore W1981631242C2781161787 @default.
• W1981631242 hasConceptScore W1981631242C2911091166 @default.
• W1981631242 hasConceptScore W1981631242C53345823 @default.
• W1981631242 hasConceptScore W1981631242C55493867 @default.
• W1981631242 hasConceptScore W1981631242C71924100 @default.
• W1981631242 hasConceptScore W1981631242C86803240 @default.
• W1981631242 hasLocation W19816312421 @default.
• W1981631242 hasLocation W19816312422 @default.
• W1981631242 hasLocation W19816312423 @default.
• W1981631242 hasLocation W19816312424 @default.

• next