FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981638442> ?p ?o ?g. }

• W1981638442 abstract "<b>JAMA</b> <b>Ginkgo biloba for Prevention of Dementia: A Randomized Controlled Trial </b> Steven T. DeKosky, MD; Jeff D. Williamson, MD, MHS; Annette L. Fitzpatrick, PhD; Richard A. Kronmal, PhD; Diane G. Ives, MPH; Judith A. Saxton, MD; Oscar L. Lopez, MD; Gregory Burke, MD; Michelle C. Carlson, PhD; Linda P. Fried, MD, MPH; Lewis H. Kuller, MD, DrPH; John A. Robbins, MD, MHS; Russell P. Tracy, PhD; Nancy F. Woolard; Leslie Dunn, MPH; Beth E. Snitz, PhD; Richard L. Nahin, PhD, MPH; Curt D. Furberg, MD, PhD; for the Ginkgo Evaluation of Memory (GEM) Study Investigators <h3>Context:</h3> <i>Ginkgo biloba</i>is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of<i>G biloba</i>on dementia incidence are lacking. <h3>Objective: </h3> To determine effectiveness of<i>G biloba</i>vs placebo in reducing the incidence of all-cause dementia and Alzheimer disease (AD) in elderly individuals with normal cognition and those with mild cognitive impairment (MCI). <h3>Design, Setting, and Participants: </h3> Randomized, double-blind, placebo-controlled clinical trial conducted in 5 academic medical centers in the United States between 2000 and 2008 with a median follow-up of 6.1 years. Three thousand sixty-nine community volunteers aged 75 years or older with normal cognition (n = 2587) or MCI (n = 482) at study entry were assessed every 6 months for incident dementia. <h3>Intervention: </h3> Twice-daily dose of 120-mg extract of<i>G biloba</i>(n = 1545) or placebo (n = 1524). <h3>Main Outcome Measures: </h3> Incident dementia and AD determined by expert panel consensus. <h3>Results: </h3> Five hundred twenty-three individuals developed dementia (246 receiving placebo and 277 receiving<i>G biloba</i>) with 92% of the dementia cases classified as possible or probable AD, or AD with evidence of vascular disease of the brain. Rates of dropout and loss to follow-up were low (6.3%), and the adverse effect profiles were similar for both groups. The overall dementia rate was 3.3 per 100 person-years in participants assigned to<i>G biloba</i>and 2.9 per 100 person-years in the placebo group. The hazard ratio (HR) for<i>G biloba</i>compared with placebo for all-cause dementia was 1.12 (95% confidence interval [CI], 0.94-1.33;<i>P</i> = .21) and for AD, 1.16 (95% CI, 0.97-1.39;<i>P</i> = .11).<i>G biloba</i>also had no effect on the rate of progression to dementia in participants with MCI (HR, 1.13; 95% CI, 0.85-1.50;<i>P</i> = .39). <h3>Conclusions: </h3> In this study,<i>G biloba</i>at 120 mg twice a day was not effective in reducing either the overall incidence rate of dementia or AD incidence in elderly individuals with normal cognition or those with MCI. <h3>Trial Registration: </h3> clinicaltrials.gov Identifier:NCT00010803 <i>JAMA. 2008;300(19):2253-2262..</i>" @default.
• W1981638442 created "2016-06-24" @default.
• W1981638442 creator A5040631126 @default.
• W1981638442 date "2009-05-01" @default.
• W1981638442 modified "2023-09-24" @default.
• W1981638442 title "Ginkgo biloba Prevention Trials" @default.
• W1981638442 cites W1736805871 @default.
• W1981638442 cites W1941528024 @default.
• W1981638442 cites W1967289410 @default.
• W1981638442 cites W1980529166 @default.
• W1981638442 cites W2000078561 @default.
• W1981638442 cites W2020971197 @default.
• W1981638442 cites W2021855470 @default.
• W1981638442 cites W2057621677 @default.
• W1981638442 cites W2082404113 @default.
• W1981638442 cites W2102698273 @default.
• W1981638442 cites W2103575664 @default.
• W1981638442 cites W2120121324 @default.
• W1981638442 cites W2128758194 @default.
• W1981638442 cites W2149467862 @default.
• W1981638442 cites W2152415998 @default.
• W1981638442 cites W2172298877 @default.
• W1981638442 doi "https://doi.org/10.1001/archneurol.2009.47" @default.
• W1981638442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19433666" @default.
• W1981638442 hasPublicationYear "2009" @default.
• W1981638442 type Work @default.
• W1981638442 sameAs 1981638442 @default.
• W1981638442 citedByCount "5" @default.
• W1981638442 countsByYear W19816384422015 @default.
• W1981638442 countsByYear W19816384422018 @default.
• W1981638442 crossrefType "journal-article" @default.
• W1981638442 hasAuthorship W1981638442A5040631126 @default.
• W1981638442 hasConcept C118552586 @default.
• W1981638442 hasConcept C126322002 @default.
• W1981638442 hasConcept C142724271 @default.
• W1981638442 hasConcept C151730666 @default.
• W1981638442 hasConcept C15744967 @default.
• W1981638442 hasConcept C168563851 @default.
• W1981638442 hasConcept C169900460 @default.
• W1981638442 hasConcept C204787440 @default.
• W1981638442 hasConcept C27081682 @default.
• W1981638442 hasConcept C2776632958 @default.
• W1981638442 hasConcept C2778998842 @default.
• W1981638442 hasConcept C2779134260 @default.
• W1981638442 hasConcept C2779343474 @default.
• W1981638442 hasConcept C2779483572 @default.
• W1981638442 hasConcept C535046627 @default.
• W1981638442 hasConcept C71924100 @default.
• W1981638442 hasConcept C74909509 @default.
• W1981638442 hasConcept C86803240 @default.
• W1981638442 hasConcept C98274493 @default.
• W1981638442 hasConceptScore W1981638442C118552586 @default.
• W1981638442 hasConceptScore W1981638442C126322002 @default.
• W1981638442 hasConceptScore W1981638442C142724271 @default.
• W1981638442 hasConceptScore W1981638442C151730666 @default.
• W1981638442 hasConceptScore W1981638442C15744967 @default.
• W1981638442 hasConceptScore W1981638442C168563851 @default.
• W1981638442 hasConceptScore W1981638442C169900460 @default.
• W1981638442 hasConceptScore W1981638442C204787440 @default.
• W1981638442 hasConceptScore W1981638442C27081682 @default.
• W1981638442 hasConceptScore W1981638442C2776632958 @default.
• W1981638442 hasConceptScore W1981638442C2778998842 @default.
• W1981638442 hasConceptScore W1981638442C2779134260 @default.
• W1981638442 hasConceptScore W1981638442C2779343474 @default.
• W1981638442 hasConceptScore W1981638442C2779483572 @default.
• W1981638442 hasConceptScore W1981638442C535046627 @default.
• W1981638442 hasConceptScore W1981638442C71924100 @default.
• W1981638442 hasConceptScore W1981638442C74909509 @default.
• W1981638442 hasConceptScore W1981638442C86803240 @default.
• W1981638442 hasConceptScore W1981638442C98274493 @default.
• W1981638442 hasIssue "5" @default.
• W1981638442 hasLocation W19816384421 @default.
• W1981638442 hasLocation W19816384422 @default.
• W1981638442 hasOpenAccess W1981638442 @default.
• W1981638442 hasPrimaryLocation W19816384421 @default.
• W1981638442 hasRelatedWork W116688419 @default.
• W1981638442 hasRelatedWork W1984404080 @default.
• W1981638442 hasRelatedWork W2037226358 @default.
• W1981638442 hasRelatedWork W2068655027 @default.
• W1981638442 hasRelatedWork W2388131358 @default.
• W1981638442 hasRelatedWork W2536367606 @default.
• W1981638442 hasRelatedWork W2747022600 @default.
• W1981638442 hasRelatedWork W2748952813 @default.
• W1981638442 hasRelatedWork W2899084033 @default.
• W1981638442 hasRelatedWork W4386100254 @default.
• W1981638442 hasVolume "66" @default.
• W1981638442 isParatext "false" @default.
• W1981638442 isRetracted "false" @default.
• W1981638442 magId "1981638442" @default.
• W1981638442 workType "article" @default.