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• W1981640557 abstract "The brain-derived neurotrophic factor (BDNF) gene is expressed in differentiating and post-mitotic neurons of the zebrafish embryo, where it has been implicated in Huntington's disease. Little is known, however, about the full complement of neuronal cell types that express BDNF in this important vertebrate model. Here, we further explored the transcriptional profiles during the first week of development using real-time quantitative polymerase chain reaction (RT-qPCR) and whole-mount in situ hybridization (WISH). RT-qPCR results revealed a high level of maternal contribution followed by a steady increase of zygotic transcription, consistent with the notion of a prominent role of BDNF in neuronal maturation and maintenance. Based on WISH, we demonstrate for the first time that BDNF expression in the developing brain of zebrafish is structure specific. Anatomical criteria and co-staining with genetic markers (shh, pax2a, emx1, krox20, lhx2b and lhx9) visualized major topological domains of BDNF-positive cells in the pallium, hypothalamus, posterior tuberculum and optic tectum. Moreover, the relative timing of BDNF transcription in the eye and tectum may illustrate a mechanism for coordinated development of the retinotectal system. Taken together, our results are compatible with a local delivery and early role of BDNF in the developing brain of zebrafish, adding basic knowledge to the study of neurotrophin functions in neural development and disease." @default.
• W1981640557 created "2016-06-24" @default.
• W1981640557 creator A5014763094 @default.
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• W1981640557 date "2014-03-04" @default.
• W1981640557 modified "2023-10-15" @default.
• W1981640557 title "Localization of<i>BDNF</i>expression in the developing brain of zebrafish" @default.
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• W1981640557 doi "https://doi.org/10.1111/joa.12168" @default.
• W1981640557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3981499" @default.
• W1981640557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24588510" @default.
• W1981640557 hasPublicationYear "2014" @default.
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