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• W1981659525 abstract "Gonadotropin-releasing hormones (GnRH) constitute a family of neuropeptides which are important regulators of reproduction in vertebrates. The effect of mammalian GnRH (mGnRH), salmon GnRH, chicken GnRH-I, chicken GnRH-II, and lamprey GnRH-I on [3H]thymidine incorporation into DNA of dissociated gonadal cells of marine bivalves has been studied. The incorporation of [3H]thymidine is linear between 1.5 and 8 h of incubation. All five GnRHs significantly increased DNA synthesis in gonial cells ofCrassostrea gigas.The maximal activation was about of 135–140% above control. The activation is dose dependent, over the range 10−11to 10−6M, but is modulated by the physiological condition of the cells and the stage of sexual maturity of the gonad. mGnRH has also a mitogenic effect in dissociated mantle cells ofMytilus edulis.The effect of mGnRH is blocked by a GnRH antagonist ([D-pGlu1,D-Phe2,D-Trp3,6]GnRH, 5 × 10−6M) inC. gigasas well as inM. edulis,suggesting that the GnRH action in the gonad is mediated by specific receptors for GnRH or GnRH-like peptides. The existence of GnRH-immunoreactive neurons and fibers in the cerebral and pedal ganglia ofM. eduliswas demonstrated by immunocytochemistry. They are located principally in the anterior internal area of the cerebral ganglia, close to the cerebral commissure and in the posterior part of the pedal ganglia. The presence of GnRH-responsive cells and GnRH-like immunoreactive material suggests that peptides of the GnRH-like family are present and functional in bivalve molluscs." @default.
• W1981659525 created "2016-06-24" @default.
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• W1981659525 date "1999-01-01" @default.
• W1981659525 modified "2023-09-27" @default.
• W1981659525 title "Effects of Five Natural Gonadotropin-Releasing Hormones on Cell Suspensions of Marine Bivalve Gonad: Stimulation of Gonial DNA Synthesis" @default.
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• W1981659525 doi "https://doi.org/10.1006/gcen.1998.7186" @default.
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