FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981668528> ?p ?o ?g. }

• W1981668528 endingPage "298" @default.
• W1981668528 startingPage "289" @default.
• W1981668528 abstract "1 The polysaccharide from Ganoderma lucidum (PS-G) has been reported to enhance immune responses and to elicit antitumor effects. In our previous study, we found that PS-G efficiently inhibited spontaneously and Fas-enhanced neutrophil apoptosis when cultured in vitro. Since phagocytosis and chemotaxis play essential roles in host defense mediated by neutrophils, it is of great interest to know the effect of PS-G on these two cell functions, and the molecular events leading to these actions. 2 Using latex beads and heat-inactive Escherichia coli serving as particles for neutrophil engulfment, we found that PS-G is able to enhance phagocytic activity of human primary neutrophils and neutrophilic-phenotype cells differentiated from all trans retinoic acid-treated HL-60 cells. 3 Chemotactic assay using Boyden chamber also revealed the ability of PS-G to increase neutrophil migration. 4 Exposure of neutrophils to PS-G time dependently caused increases in protein kinase C (PKC), p38 mitogen-activated protein kinase (MAPK), Hck, and Lyn activities. 5 Results with specific kinase inhibitors indicate that phagocytic action of PS-G was reduced by the presence of wortmannin (Phosphatidylinositol 3-kinase, PI3K inhibitor), pyrazolpyrimidine 2 (Src-family tyrosine kinase inhibitor), Ro318220 (PKC inhibitor), and SB203580 (p38 MAPK inhibitor), but not by PD98059 (mitogen-activated protein/ERK kinase inhibitor). Moreover, chemotactic action of PS-G requires the activities of PI3K, p38 MAPK, Src tyrosine kinases and PKC. 6 All these results demonstrate the abilities of PS-G to enhance neutrophil function in phagocytosis and chemotaxis, and further provide evidence to strengthen the beneficial remedy of G. lucidum in human to enhance defense system." @default.
• W1981668528 created "2016-06-24" @default.
• W1981668528 creator A5012713190 @default.
• W1981668528 creator A5028057825 @default.
• W1981668528 creator A5056754858 @default.
• W1981668528 creator A5069501364 @default.
• W1981668528 date "2003-05-01" @default.
• W1981668528 modified "2023-10-16" @default.
• W1981668528 title "Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from<i>Ganoderma lucidum</i>" @default.
• W1981668528 cites W1480405375 @default.
• W1981668528 cites W1514798834 @default.
• W1981668528 cites W1515006217 @default.
• W1981668528 cites W1520041833 @default.
• W1981668528 cites W1609249008 @default.
• W1981668528 cites W1614687985 @default.
• W1981668528 cites W1891774658 @default.
• W1981668528 cites W1973775002 @default.
• W1981668528 cites W1985830927 @default.
• W1981668528 cites W1989739077 @default.
• W1981668528 cites W1991767888 @default.
• W1981668528 cites W1997620264 @default.
• W1981668528 cites W2000949003 @default.
• W1981668528 cites W2001587733 @default.
• W1981668528 cites W2013315740 @default.
• W1981668528 cites W2013650179 @default.
• W1981668528 cites W2014324389 @default.
• W1981668528 cites W2014520088 @default.
• W1981668528 cites W2015665878 @default.
• W1981668528 cites W2017635894 @default.
• W1981668528 cites W2020397881 @default.
• W1981668528 cites W2046213019 @default.
• W1981668528 cites W2048198814 @default.
• W1981668528 cites W2049136865 @default.
• W1981668528 cites W2055635848 @default.
• W1981668528 cites W2062353253 @default.
• W1981668528 cites W2067778098 @default.
• W1981668528 cites W2068464511 @default.
• W1981668528 cites W2068939504 @default.
• W1981668528 cites W2075841818 @default.
• W1981668528 cites W2077907680 @default.
• W1981668528 cites W2085871805 @default.
• W1981668528 cites W2105256758 @default.
• W1981668528 cites W2109860344 @default.
• W1981668528 cites W2123376396 @default.
• W1981668528 cites W2132252339 @default.
• W1981668528 cites W2145332455 @default.
• W1981668528 cites W2148418293 @default.
• W1981668528 cites W2155996040 @default.
• W1981668528 cites W2170992468 @default.
• W1981668528 cites W2182956311 @default.
• W1981668528 cites W2333011916 @default.
• W1981668528 cites W2362505443 @default.
• W1981668528 cites W2949187278 @default.
• W1981668528 cites W4322388490 @default.
• W1981668528 doi "https://doi.org/10.1038/sj.bjp.0705243" @default.
• W1981668528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573843" @default.
• W1981668528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12770934" @default.
• W1981668528 hasPublicationYear "2003" @default.
• W1981668528 type Work @default.
• W1981668528 sameAs 1981668528 @default.
• W1981668528 citedByCount "77" @default.
• W1981668528 countsByYear W19816685282012 @default.
• W1981668528 countsByYear W19816685282013 @default.
• W1981668528 countsByYear W19816685282014 @default.
• W1981668528 countsByYear W19816685282015 @default.
• W1981668528 countsByYear W19816685282017 @default.
• W1981668528 countsByYear W19816685282018 @default.
• W1981668528 countsByYear W19816685282019 @default.
• W1981668528 countsByYear W19816685282020 @default.
• W1981668528 countsByYear W19816685282021 @default.
• W1981668528 countsByYear W19816685282022 @default.
• W1981668528 countsByYear W19816685282023 @default.
• W1981668528 crossrefType "journal-article" @default.
• W1981668528 hasAuthorship W1981668528A5012713190 @default.
• W1981668528 hasAuthorship W1981668528A5028057825 @default.
• W1981668528 hasAuthorship W1981668528A5056754858 @default.
• W1981668528 hasAuthorship W1981668528A5069501364 @default.
• W1981668528 hasBestOaLocation W19816685281 @default.
• W1981668528 hasConcept C108636557 @default.
• W1981668528 hasConcept C132149769 @default.
• W1981668528 hasConcept C153911025 @default.
• W1981668528 hasConcept C160448771 @default.
• W1981668528 hasConcept C170493617 @default.
• W1981668528 hasConcept C175818844 @default.
• W1981668528 hasConcept C184235292 @default.
• W1981668528 hasConcept C185592680 @default.
• W1981668528 hasConcept C195794163 @default.
• W1981668528 hasConcept C2778308172 @default.
• W1981668528 hasConcept C2780610907 @default.
• W1981668528 hasConcept C51551487 @default.
• W1981668528 hasConcept C54166955 @default.
• W1981668528 hasConcept C55493867 @default.
• W1981668528 hasConcept C57074206 @default.
• W1981668528 hasConcept C86803240 @default.
• W1981668528 hasConcept C95444343 @default.
• W1981668528 hasConcept C97029542 @default.
• W1981668528 hasConceptScore W1981668528C108636557 @default.
• W1981668528 hasConceptScore W1981668528C132149769 @default.

• next