Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981736284> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1981736284 endingPage "S85" @default.
- W1981736284 startingPage "S80" @default.
- W1981736284 abstract "Loracarbef (LY163892), a member of the class of beta-lactam antibiotics known as carbacephems, is characterized by a high level of chemical stability and a broad spectrum of antibacterial activity that persists in the presence of beta-lactamase. The efficacy and safety of loracarbef, 200 mg (twice daily), and cefaclor, 250 mg (three times daily) (one patient received 178 mg of cefaclor suspension, three times daily), were compared in a randomized, double-blind, multicenter trial conducted in adults with skin and skin-structure infections due predominantly to Staphylococcus aureus. Examination within 72 hours after the completion of therapy indicated a favorable clinical response in 84 (93.3%) of the 90 loracarbef-treated patients evaluable for efficacy and in 79 (95.2%) of the 83 evaluable patients treated with cefaclor. Pathogens were eradicated in 83 (92.2%) of the patients in the loracarbef group and 74 (89.2%) of those in the cefaclor group. Only four adverse events--headache/migraine, diarrhea, abdominal pain, and nausea--occurred in greater than 2% of the total study population. The overall incidence of adverse events in the 201 loracarbef-treated and 192 cefaclor-treated patients evaluated for safety was 19.9% and 24.5%, respectively. Adverse events that required hospitalization or discontinuation of treatment occurred in four patients in the cefaclor group but in none of those treated with loracarbef. There were no statistically significant differences in the clinical or bacteriologic response or the incidence of side effects between the two treatment groups. These findings indicate that loracarbef given twice daily is comparable in safety and efficacy to cefaclor given three times daily in the treatment of adults with skin and skin-structure infections." @default.
- W1981736284 created "2016-06-24" @default.
- W1981736284 creator A5027687514 @default.
- W1981736284 creator A5071309765 @default.
- W1981736284 creator A5073660614 @default.
- W1981736284 date "1992-06-01" @default.
- W1981736284 modified "2023-09-27" @default.
- W1981736284 title "Loracarbef (LY163892) versus cefaclor in the treatment of bacterial skin and skin-structure infections in an adult population" @default.
- W1981736284 cites W1977209051 @default.
- W1981736284 cites W1981485975 @default.
- W1981736284 cites W1991785257 @default.
- W1981736284 cites W2045473925 @default.
- W1981736284 cites W2058231634 @default.
- W1981736284 cites W2069947800 @default.
- W1981736284 cites W2331178639 @default.
- W1981736284 doi "https://doi.org/10.1016/0002-9343(92)90613-g" @default.
- W1981736284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1621751" @default.
- W1981736284 hasPublicationYear "1992" @default.
- W1981736284 type Work @default.
- W1981736284 sameAs 1981736284 @default.
- W1981736284 citedByCount "17" @default.
- W1981736284 countsByYear W19817362842012 @default.
- W1981736284 crossrefType "journal-article" @default.
- W1981736284 hasAuthorship W1981736284A5027687514 @default.
- W1981736284 hasAuthorship W1981736284A5071309765 @default.
- W1981736284 hasAuthorship W1981736284A5073660614 @default.
- W1981736284 hasConcept C120665830 @default.
- W1981736284 hasConcept C121332964 @default.
- W1981736284 hasConcept C126322002 @default.
- W1981736284 hasConcept C197934379 @default.
- W1981736284 hasConcept C2778375690 @default.
- W1981736284 hasConcept C2778715236 @default.
- W1981736284 hasConcept C2779766023 @default.
- W1981736284 hasConcept C2780580376 @default.
- W1981736284 hasConcept C2780852908 @default.
- W1981736284 hasConcept C2908647359 @default.
- W1981736284 hasConcept C501593827 @default.
- W1981736284 hasConcept C61511704 @default.
- W1981736284 hasConcept C64778159 @default.
- W1981736284 hasConcept C71924100 @default.
- W1981736284 hasConcept C86803240 @default.
- W1981736284 hasConcept C89423630 @default.
- W1981736284 hasConcept C90924648 @default.
- W1981736284 hasConcept C99454951 @default.
- W1981736284 hasConceptScore W1981736284C120665830 @default.
- W1981736284 hasConceptScore W1981736284C121332964 @default.
- W1981736284 hasConceptScore W1981736284C126322002 @default.
- W1981736284 hasConceptScore W1981736284C197934379 @default.
- W1981736284 hasConceptScore W1981736284C2778375690 @default.
- W1981736284 hasConceptScore W1981736284C2778715236 @default.
- W1981736284 hasConceptScore W1981736284C2779766023 @default.
- W1981736284 hasConceptScore W1981736284C2780580376 @default.
- W1981736284 hasConceptScore W1981736284C2780852908 @default.
- W1981736284 hasConceptScore W1981736284C2908647359 @default.
- W1981736284 hasConceptScore W1981736284C501593827 @default.
- W1981736284 hasConceptScore W1981736284C61511704 @default.
- W1981736284 hasConceptScore W1981736284C64778159 @default.
- W1981736284 hasConceptScore W1981736284C71924100 @default.
- W1981736284 hasConceptScore W1981736284C86803240 @default.
- W1981736284 hasConceptScore W1981736284C89423630 @default.
- W1981736284 hasConceptScore W1981736284C90924648 @default.
- W1981736284 hasConceptScore W1981736284C99454951 @default.
- W1981736284 hasIssue "6" @default.
- W1981736284 hasLocation W19817362841 @default.
- W1981736284 hasLocation W19817362842 @default.
- W1981736284 hasOpenAccess W1981736284 @default.
- W1981736284 hasPrimaryLocation W19817362841 @default.
- W1981736284 hasRelatedWork W1492384425 @default.
- W1981736284 hasRelatedWork W1972179746 @default.
- W1981736284 hasRelatedWork W2068354996 @default.
- W1981736284 hasRelatedWork W2104761597 @default.
- W1981736284 hasRelatedWork W2156337883 @default.
- W1981736284 hasRelatedWork W2372442000 @default.
- W1981736284 hasRelatedWork W2384102814 @default.
- W1981736284 hasRelatedWork W2394317912 @default.
- W1981736284 hasRelatedWork W2528959283 @default.
- W1981736284 hasRelatedWork W2183331092 @default.
- W1981736284 hasVolume "92" @default.
- W1981736284 isParatext "false" @default.
- W1981736284 isRetracted "false" @default.
- W1981736284 magId "1981736284" @default.
- W1981736284 workType "article" @default.