Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981755815> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1981755815 endingPage "1443" @default.
- W1981755815 startingPage "1438" @default.
- W1981755815 abstract "By studying the characteristics of BHR in subjects clearly defined as having asthma or COPD, it is apparent that there are both similarities and differences. These responses can be broadly explained in terms of present knowledge of the pathologic features and the mechanisms causing the abnormalities in the two diseases, and they highlight the important differences between the diseases.It seems likely that tests of BHR with histamine and methacholine cannot be used to distinguish asthma from COPD in subjects with a mild decrease in FEV1 and symptoms that do not clearly suggest asthma or COPD. However, a dose-response curve to methacholine is helpful. If there is a plateau, and the PD20 FEV1 is more than 4.0 µmol, it is unlikely to be asthma. If there is no plateau, a test with propranolol or SO2 may be useful to discriminate the two diseases. The similarities in the responses—especially those to histamine — explain why there is frequently difficulty in deciding the nature of the disease present in an individual subject.Is it important to distinguish the two diseases? In the introduction it was suggested that it is important for understanding these diseases, for prognosis, for treatment, and ultimately for prevention. It remains difficult to determine prognosis from any single test of bronchial responsiveness, and response to prophylaxis (stopping smoking, allergen avoidance) plus drug treatment over several years is probably needed to predict outcome in an individual patient.Finally, despite the valid hypothesis proposed by Orie and coworkers (2), it seems unlikely that studying the characteristics of BHR will shed light on the “host” factors present in both diseases that remain poorly understood." @default.
- W1981755815 created "2016-06-24" @default.
- W1981755815 creator A5027161698 @default.
- W1981755815 creator A5048115285 @default.
- W1981755815 creator A5060990024 @default.
- W1981755815 creator A5061628334 @default.
- W1981755815 creator A5065988559 @default.
- W1981755815 creator A5073010557 @default.
- W1981755815 creator A5075584909 @default.
- W1981755815 date "1991-06-01" @default.
- W1981755815 modified "2023-09-23" @default.
- W1981755815 title "Characteristics of Bronchial Hyperresponsiveness in Chronic Obstructive Pulmonary Disease and in Asthma" @default.
- W1981755815 cites W1964793578 @default.
- W1981755815 cites W1980909800 @default.
- W1981755815 cites W2019588207 @default.
- W1981755815 cites W2036008132 @default.
- W1981755815 cites W2073615621 @default.
- W1981755815 doi "https://doi.org/10.1164/ajrccm/143.6.1438" @default.
- W1981755815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2048834" @default.
- W1981755815 hasPublicationYear "1991" @default.
- W1981755815 type Work @default.
- W1981755815 sameAs 1981755815 @default.
- W1981755815 citedByCount "61" @default.
- W1981755815 countsByYear W19817558152012 @default.
- W1981755815 countsByYear W19817558152013 @default.
- W1981755815 countsByYear W19817558152015 @default.
- W1981755815 countsByYear W19817558152016 @default.
- W1981755815 countsByYear W19817558152017 @default.
- W1981755815 countsByYear W19817558152018 @default.
- W1981755815 countsByYear W19817558152020 @default.
- W1981755815 countsByYear W19817558152021 @default.
- W1981755815 crossrefType "journal-article" @default.
- W1981755815 hasAuthorship W1981755815A5027161698 @default.
- W1981755815 hasAuthorship W1981755815A5048115285 @default.
- W1981755815 hasAuthorship W1981755815A5060990024 @default.
- W1981755815 hasAuthorship W1981755815A5061628334 @default.
- W1981755815 hasAuthorship W1981755815A5065988559 @default.
- W1981755815 hasAuthorship W1981755815A5073010557 @default.
- W1981755815 hasAuthorship W1981755815A5075584909 @default.
- W1981755815 hasConcept C1122143 @default.
- W1981755815 hasConcept C126322002 @default.
- W1981755815 hasConcept C177713679 @default.
- W1981755815 hasConcept C203014093 @default.
- W1981755815 hasConcept C2776042228 @default.
- W1981755815 hasConcept C2776178081 @default.
- W1981755815 hasConcept C2776238763 @default.
- W1981755815 hasConcept C2776780178 @default.
- W1981755815 hasConcept C2777714996 @default.
- W1981755815 hasConcept C2779134260 @default.
- W1981755815 hasConcept C2781260171 @default.
- W1981755815 hasConcept C71924100 @default.
- W1981755815 hasConceptScore W1981755815C1122143 @default.
- W1981755815 hasConceptScore W1981755815C126322002 @default.
- W1981755815 hasConceptScore W1981755815C177713679 @default.
- W1981755815 hasConceptScore W1981755815C203014093 @default.
- W1981755815 hasConceptScore W1981755815C2776042228 @default.
- W1981755815 hasConceptScore W1981755815C2776178081 @default.
- W1981755815 hasConceptScore W1981755815C2776238763 @default.
- W1981755815 hasConceptScore W1981755815C2776780178 @default.
- W1981755815 hasConceptScore W1981755815C2777714996 @default.
- W1981755815 hasConceptScore W1981755815C2779134260 @default.
- W1981755815 hasConceptScore W1981755815C2781260171 @default.
- W1981755815 hasConceptScore W1981755815C71924100 @default.
- W1981755815 hasIssue "6" @default.
- W1981755815 hasLocation W19817558151 @default.
- W1981755815 hasLocation W19817558152 @default.
- W1981755815 hasOpenAccess W1981755815 @default.
- W1981755815 hasPrimaryLocation W19817558151 @default.
- W1981755815 hasRelatedWork W1793806683 @default.
- W1981755815 hasRelatedWork W1967440690 @default.
- W1981755815 hasRelatedWork W1969727290 @default.
- W1981755815 hasRelatedWork W1981696827 @default.
- W1981755815 hasRelatedWork W2033927493 @default.
- W1981755815 hasRelatedWork W2072039445 @default.
- W1981755815 hasRelatedWork W2135946482 @default.
- W1981755815 hasRelatedWork W2163627486 @default.
- W1981755815 hasRelatedWork W2391201281 @default.
- W1981755815 hasRelatedWork W3145135515 @default.
- W1981755815 hasVolume "143" @default.
- W1981755815 isParatext "false" @default.
- W1981755815 isRetracted "false" @default.
- W1981755815 magId "1981755815" @default.
- W1981755815 workType "article" @default.