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- W1981758908 abstract "A tremor monitor was constructed and tested that quantitates soman- and oxotremorine-induced tremors. The device consisted of a force transducer, from which was suspended a plastic beaker containing a mouse. The signal from the force transducer was fed into a tremor monitor, which was essentially a low-pass filter, and quantitated using the Applecounter from Columbus Instruments (Columbus, Ohio) with the data stored on floppy diskette in a personal computer or on a magnetic tape cassette. The tremor monitor demonstrated a dose response relationship to both soman- and oxotremorine-induced tremors and the antagonism of these tremors by various doses of atropine. In addition, the duration of action of a dose of atropine (17.4 mg/kg, ip) normally used in the therapy of organophosphate poisoning was assessed using the atropine antagonism of oxotremorine-induced tremors as an indicator. This device permits the unbiased determination of the tremor activity of a drug and allows the use of statistical analysis on the data produced." @default.
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- W1981758908 date "1989-08-01" @default.
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- W1981758908 title "Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors." @default.
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- W1981758908 doi "https://doi.org/10.1016/0160-5402(89)90048-x" @default.
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