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- W1981771331 abstract "Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed." @default.
- W1981771331 created "2016-06-24" @default.
- W1981771331 creator A5049703409 @default.
- W1981771331 creator A5073490663 @default.
- W1981771331 date "2014-01-01" @default.
- W1981771331 modified "2023-09-28" @default.
- W1981771331 title "Vitamin D and chronic kidney disease" @default.
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- W1981771331 doi "https://doi.org/10.3904/kjim.2014.29.4.416" @default.
- W1981771331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4101586" @default.
- W1981771331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25045287" @default.
- W1981771331 hasPublicationYear "2014" @default.
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