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• W1981776258 abstract "Abnormalities of serotonin synthesis and metabolism may be associated with suicidality. The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. We examined the association of suicidal behavior in Chinese schizophrenic patients with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal and 262 non-suicidal patients with a diagnosis of schizophrenia (DSM-IV criteria). All subjects were unrelated to each other, and all were Chinese. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with history of attempted suicide. From our results, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behavior in Chinese patients with schizophrenia." @default.
• W1981776258 created "2016-06-24" @default.
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• W1981776258 date "2000-12-01" @default.
• W1981776258 modified "2023-09-30" @default.
• W1981776258 title "Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia" @default.
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• W1981776258 doi "https://doi.org/10.1016/s0165-1781(00)00229-8" @default.
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