Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981782811> ?p ?o ?g. }
- W1981782811 endingPage "314" @default.
- W1981782811 startingPage "311" @default.
- W1981782811 abstract "Metformin has been shown to inhibit the growth of endometriotic implants, and reverse endometrial hyperplasia when combined with oral contraceptive in a case report. The aim of this study is to compare the antiproliferative effects of medroxyprogesterone acetate (MPA), and metformin in oopherectomized rat endometrium. Forty oopherectomized Wistar-Albino rats were used, and assigned to receive saline, 17 β Estradiol hemihydrate (4 mg/kg), 17 β Estradiol hemihydrate (4 mg/kg) and metformin (50 mg/kg), 17 β Estradiol hemihydrate (4 mg/kg) and MPA (1 mg/day) for 14 days. Histological markers of uterotrophy, including endometrial height, luminal ephitelial cell height and density of endometrial glands on hysterectomy speciments were quantified for each specimen. Rats treated with estradiol had significantly increased in endometrial height, endomerial luminal epithelial height and endometrial gland densitiy than the other groups. Metformin and MPA acetate significantly reduced all parameters indicating endometrial hyperplasia, and uterotrophy with respect to the control group. Antiproliferative effects of metformin, and MPA was found to be comparable for all three parameters. In conclusion, metformin attenuates estrogen-induced endometrial hyperplasia in ooferectomized rats to the same degree as progesterone." @default.
- W1981782811 created "2016-06-24" @default.
- W1981782811 creator A5019116663 @default.
- W1981782811 creator A5020821981 @default.
- W1981782811 creator A5024784677 @default.
- W1981782811 creator A5054809680 @default.
- W1981782811 creator A5065257673 @default.
- W1981782811 creator A5079043595 @default.
- W1981782811 date "2013-01-10" @default.
- W1981782811 modified "2023-10-12" @default.
- W1981782811 title "Comparison of antiproliferative effects of metformine and progesterone on estrogen-induced endometrial hyperplasia in rats" @default.
- W1981782811 cites W1933506009 @default.
- W1981782811 cites W1971310926 @default.
- W1981782811 cites W1980498769 @default.
- W1981782811 cites W1986763334 @default.
- W1981782811 cites W1995795826 @default.
- W1981782811 cites W1997235289 @default.
- W1981782811 cites W2002052645 @default.
- W1981782811 cites W2007956592 @default.
- W1981782811 cites W2012916349 @default.
- W1981782811 cites W2032541799 @default.
- W1981782811 cites W2035887422 @default.
- W1981782811 cites W2036801027 @default.
- W1981782811 cites W2040619536 @default.
- W1981782811 cites W2043933121 @default.
- W1981782811 cites W2046679467 @default.
- W1981782811 cites W2051508079 @default.
- W1981782811 cites W2082521320 @default.
- W1981782811 cites W2082736240 @default.
- W1981782811 cites W2087814078 @default.
- W1981782811 cites W2101978889 @default.
- W1981782811 cites W2112411701 @default.
- W1981782811 cites W2122246361 @default.
- W1981782811 cites W2122289929 @default.
- W1981782811 cites W2141662760 @default.
- W1981782811 cites W2142177247 @default.
- W1981782811 cites W2143635979 @default.
- W1981782811 cites W2144500191 @default.
- W1981782811 cites W2150683930 @default.
- W1981782811 cites W2152351556 @default.
- W1981782811 cites W2162695110 @default.
- W1981782811 cites W2170843315 @default.
- W1981782811 cites W2172206570 @default.
- W1981782811 cites W2472355735 @default.
- W1981782811 doi "https://doi.org/10.3109/09513590.2012.743010" @default.
- W1981782811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23305503" @default.
- W1981782811 hasPublicationYear "2013" @default.
- W1981782811 type Work @default.
- W1981782811 sameAs 1981782811 @default.
- W1981782811 citedByCount "22" @default.
- W1981782811 countsByYear W19817828112014 @default.
- W1981782811 countsByYear W19817828112015 @default.
- W1981782811 countsByYear W19817828112016 @default.
- W1981782811 countsByYear W19817828112017 @default.
- W1981782811 countsByYear W19817828112019 @default.
- W1981782811 countsByYear W19817828112020 @default.
- W1981782811 countsByYear W19817828112022 @default.
- W1981782811 countsByYear W19817828112023 @default.
- W1981782811 crossrefType "journal-article" @default.
- W1981782811 hasAuthorship W1981782811A5019116663 @default.
- W1981782811 hasAuthorship W1981782811A5020821981 @default.
- W1981782811 hasAuthorship W1981782811A5024784677 @default.
- W1981782811 hasAuthorship W1981782811A5054809680 @default.
- W1981782811 hasAuthorship W1981782811A5065257673 @default.
- W1981782811 hasAuthorship W1981782811A5079043595 @default.
- W1981782811 hasConcept C121608353 @default.
- W1981782811 hasConcept C126322002 @default.
- W1981782811 hasConcept C134018914 @default.
- W1981782811 hasConcept C2775934596 @default.
- W1981782811 hasConcept C2776306185 @default.
- W1981782811 hasConcept C2777088508 @default.
- W1981782811 hasConcept C2777164284 @default.
- W1981782811 hasConcept C2777562237 @default.
- W1981782811 hasConcept C2777689261 @default.
- W1981782811 hasConcept C2778001906 @default.
- W1981782811 hasConcept C2779742232 @default.
- W1981782811 hasConcept C2780323712 @default.
- W1981782811 hasConcept C555293320 @default.
- W1981782811 hasConcept C71924100 @default.
- W1981782811 hasConceptScore W1981782811C121608353 @default.
- W1981782811 hasConceptScore W1981782811C126322002 @default.
- W1981782811 hasConceptScore W1981782811C134018914 @default.
- W1981782811 hasConceptScore W1981782811C2775934596 @default.
- W1981782811 hasConceptScore W1981782811C2776306185 @default.
- W1981782811 hasConceptScore W1981782811C2777088508 @default.
- W1981782811 hasConceptScore W1981782811C2777164284 @default.
- W1981782811 hasConceptScore W1981782811C2777562237 @default.
- W1981782811 hasConceptScore W1981782811C2777689261 @default.
- W1981782811 hasConceptScore W1981782811C2778001906 @default.
- W1981782811 hasConceptScore W1981782811C2779742232 @default.
- W1981782811 hasConceptScore W1981782811C2780323712 @default.
- W1981782811 hasConceptScore W1981782811C555293320 @default.
- W1981782811 hasConceptScore W1981782811C71924100 @default.
- W1981782811 hasIssue "4" @default.
- W1981782811 hasLocation W19817828111 @default.
- W1981782811 hasLocation W19817828112 @default.
- W1981782811 hasOpenAccess W1981782811 @default.
- W1981782811 hasPrimaryLocation W19817828111 @default.