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• W1981784186 abstract "A novel series of formoterol–phthalazinone hybrids were synthesised and evaluated as dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Most of the hybrids displayed high β2-adrenoceptor agonist and moderate PDE4 inhibitory activities. The most potent compound, (R,R)-11c, exhibited agonist (EC50 = 1.05 nM, pEC50 = 9.0) and potent PDE4B2 inhibitory activities (IC50 = 0.092 μM)." @default.
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• W1981784186 date "2014-01-01" @default.
• W1981784186 modified "2023-09-27" @default.
• W1981784186 title "Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors" @default.
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• W1981784186 doi "https://doi.org/10.1016/j.bmcl.2013.11.028" @default.
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