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• W1981786543 abstract "The dorsal striatum has been implicated in reward-based decision making, but the role played by specific striatal circuits in these processes is essentially unknown. Using cell phenotype-specific viral vectors to express engineered G-protein-coupled DREADD (designer receptors exclusively activated by designer drugs) receptors, we enhanced G_i/o- or G_s-protein-mediated signaling selectively in direct-pathway (striatonigral) neurons of the dorsomedial striatum in Long–Evans rats during discrete periods of training of a high versus low reward-discrimination task. Surprisingly, these perturbations had no impact on reward preference, task performance, or improvement of performance during training. However, we found that transiently increasing G_i/o signaling during training significantly impaired the retention of task strategies used to maximize reward obtainment during subsequent preference testing, whereas increasing G_s signaling produced the opposite effect and significantly enhanced the encoding of a high-reward preference in this decision-making task. Thus, the fact that the endurance of this improved performance was significantly altered over time—long after these neurons were manipulated—indicates that it is under bidirectional control of canonical G-protein-mediated signaling in striatonigral neurons during training. These data demonstrate that cAMP-dependent signaling in direct-pathway neurons play a well-defined role in reward-related behavior; that is, they modulate the plasticity required for the retention of task-specific information that is used to improve performance on future renditions of the task." @default.
• W1981786543 created "2016-06-24" @default.
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• W1981786543 date "2013-07-10" @default.
• W1981786543 modified "2023-10-18" @default.
• W1981786543 title "Direct-Pathway Striatal Neurons Regulate the Retention of Decision-Making Strategies" @default.
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• W1981786543 doi "https://doi.org/10.1523/jneurosci.4783-12.2013" @default.
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