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- W1981795622 abstract "Following giving birth, many women require antidepressant therapy to treat preexisting or post-partum depression. Treatment of depressed lactating women is complicated by the need to consider carefully the effects of therapy on the infants. In the present study, levels of the selective serotonin reuptake inhibitor (SSRI) citalopram were determined in breast milk of lactating women. Ten breast milk samples were collected from seven different women after treatment with citalopram 20–80 mg/day. Samples were usually obtained 12–13 hours post-dose. Levels of citalopram were measured by reverse-phase HPLC with UV detection. Citalopram was detected in all milk samples. Consistent with what has been previously reported for serum, milk levels of citalopram’s metabolites were in all cases lower than those of the parent compound. The dose of citalopram received by the infants was estimated to be about 0.03 mg/kg/day. No adverse events or unusual behavior was observed in the infants. These results confirm that infants of lactating mothers treated with citalopram receive a very small amount of this SSRI. Further, the dose of citalopram received by breast-fed infants does not appear to produce any significant effects." @default.
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- W1981795622 date "2000-04-01" @default.
- W1981795622 modified "2023-09-26" @default.
- W1981795622 title "491. Citalopram treatment and breast-feeding" @default.
- W1981795622 doi "https://doi.org/10.1016/s0006-3223(00)00761-7" @default.
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