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- W1981799493 abstract "A rapid microanalytical method is described for phenobarbital, phenytoin, primidone and carbamazepine utilizing high-performance thin-layer chromatography (HPTLC). This procedure incorporates a single extraction of a 50-microliter plasma sample. One tenth of the extract is concentrated and applied to the HPTLC plate by a Contact Spotter, chromatographically separated and quantitated by in situ ultraviolet reflectance densitometry. The coefficient of variation is less than 4% (n = 8), the extraction efficiency is approximately 95% and the minimum detectable amount of pure drug standards applied to and developed on the HPTLC plate is 5 ng or less for all four anticonvulsants." @default.
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- W1981799493 date "1981-02-01" @default.
- W1981799493 modified "2023-10-14" @default.
- W1981799493 title "Rapid microanalysis of anticonvulsants by high-performance thin-layer chromatography" @default.
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- W1981799493 doi "https://doi.org/10.1016/s0378-4347(00)81059-2" @default.
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