FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981805168> ?p ?o ?g. }

• W1981805168 endingPage "31" @default.
• W1981805168 startingPage "21" @default.
• W1981805168 abstract "The potential application of highly biocompatible o/w microemulsions as topical drug carrier systems for the percutaneous delivery of anti-inflammatory drugs, i.e. ketoprofen, was investigated. Microemulsions were made up of triglycerides as oil phase, a mixture of lecithin and n-butanol as a surfactant/co-surfactant system and an aqueous solution as the external phase. To evaluate the percutaneous enhancing effect of oleic acid, this compound was used as a component of some o/w microemulsions. The topical carrier potentialities of lecithin-based o/w microemulsions were compared with respect to conventional formulations, i.e. a w/o emulsion, a o/w emulsion and a gel. Physicochemical characterisation of microemulsions was carried out by light scattering and zeta potential analyses. Microemulsions showed mean droplet size < 35 nm and a negative zeta potential, that is -39.5 mV for the oleic acid-lecithin microemulsion and -19.7 mV for the lecithin-based microemulsion. The percutaneous adsorption of the various topical formulations was evaluated through healthy adult human skin, which was obtained from abdominal reduction surgery. Ketoprofen-loaded microemulsions showed an enhanced permeation through human skin with respect to conventional formulations. No significant percutaneous enhancer effect was observed for ketoprofen-loaded oleic acid-lecithin microemulsions. The human skin tolerability of various microemulsion formulations was evaluated on human volunteers. Microemulsions showed a good human skin tolerability." @default.
• W1981805168 created "2016-06-24" @default.
• W1981805168 creator A5020233680 @default.
• W1981805168 creator A5045468852 @default.
• W1981805168 creator A5076268781 @default.
• W1981805168 creator A5077950251 @default.
• W1981805168 creator A5081782283 @default.
• W1981805168 date "2002-09-01" @default.
• W1981805168 modified "2023-09-27" @default.
• W1981805168 title "Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability" @default.
• W1981805168 cites W1972913560 @default.
• W1981805168 cites W1975915806 @default.
• W1981805168 cites W1988843459 @default.
• W1981805168 cites W1991995598 @default.
• W1981805168 cites W2007623439 @default.
• W1981805168 cites W2008897710 @default.
• W1981805168 cites W2023183853 @default.
• W1981805168 cites W2023187823 @default.
• W1981805168 cites W2033509406 @default.
• W1981805168 cites W2034551249 @default.
• W1981805168 cites W2045800643 @default.
• W1981805168 cites W2052572695 @default.
• W1981805168 cites W2053233427 @default.
• W1981805168 cites W2053274664 @default.
• W1981805168 cites W2055995105 @default.
• W1981805168 cites W2058902945 @default.
• W1981805168 cites W2063714668 @default.
• W1981805168 cites W2064805272 @default.
• W1981805168 cites W2074887198 @default.
• W1981805168 cites W2080505046 @default.
• W1981805168 cites W2094327592 @default.
• W1981805168 cites W2131447732 @default.
• W1981805168 cites W2141331305 @default.
• W1981805168 cites W2165751567 @default.
• W1981805168 cites W2318559650 @default.
• W1981805168 doi "https://doi.org/10.1016/s0378-5173(02)00295-8" @default.
• W1981805168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12204562" @default.
• W1981805168 hasPublicationYear "2002" @default.
• W1981805168 type Work @default.
• W1981805168 sameAs 1981805168 @default.
• W1981805168 citedByCount "181" @default.
• W1981805168 countsByYear W19818051682012 @default.
• W1981805168 countsByYear W19818051682013 @default.
• W1981805168 countsByYear W19818051682014 @default.
• W1981805168 countsByYear W19818051682015 @default.
• W1981805168 countsByYear W19818051682016 @default.
• W1981805168 countsByYear W19818051682017 @default.
• W1981805168 countsByYear W19818051682018 @default.
• W1981805168 countsByYear W19818051682019 @default.
• W1981805168 countsByYear W19818051682020 @default.
• W1981805168 countsByYear W19818051682021 @default.
• W1981805168 countsByYear W19818051682022 @default.
• W1981805168 countsByYear W19818051682023 @default.
• W1981805168 crossrefType "journal-article" @default.
• W1981805168 hasAuthorship W1981805168A5020233680 @default.
• W1981805168 hasAuthorship W1981805168A5045468852 @default.
• W1981805168 hasAuthorship W1981805168A5076268781 @default.
• W1981805168 hasAuthorship W1981805168A5077950251 @default.
• W1981805168 hasAuthorship W1981805168A5081782283 @default.
• W1981805168 hasConcept C155672457 @default.
• W1981805168 hasConcept C171250308 @default.
• W1981805168 hasConcept C185592680 @default.
• W1981805168 hasConcept C190119865 @default.
• W1981805168 hasConcept C192562407 @default.
• W1981805168 hasConcept C197934379 @default.
• W1981805168 hasConcept C205679159 @default.
• W1981805168 hasConcept C2778375690 @default.
• W1981805168 hasConcept C2779564620 @default.
• W1981805168 hasConcept C2780744026 @default.
• W1981805168 hasConcept C2781403372 @default.
• W1981805168 hasConcept C43617362 @default.
• W1981805168 hasConcept C55493867 @default.
• W1981805168 hasConcept C58226133 @default.
• W1981805168 hasConcept C71924100 @default.
• W1981805168 hasConcept C86181022 @default.
• W1981805168 hasConcept C98274493 @default.
• W1981805168 hasConceptScore W1981805168C155672457 @default.
• W1981805168 hasConceptScore W1981805168C171250308 @default.
• W1981805168 hasConceptScore W1981805168C185592680 @default.
• W1981805168 hasConceptScore W1981805168C190119865 @default.
• W1981805168 hasConceptScore W1981805168C192562407 @default.
• W1981805168 hasConceptScore W1981805168C197934379 @default.
• W1981805168 hasConceptScore W1981805168C205679159 @default.
• W1981805168 hasConceptScore W1981805168C2778375690 @default.
• W1981805168 hasConceptScore W1981805168C2779564620 @default.
• W1981805168 hasConceptScore W1981805168C2780744026 @default.
• W1981805168 hasConceptScore W1981805168C2781403372 @default.
• W1981805168 hasConceptScore W1981805168C43617362 @default.
• W1981805168 hasConceptScore W1981805168C55493867 @default.
• W1981805168 hasConceptScore W1981805168C58226133 @default.
• W1981805168 hasConceptScore W1981805168C71924100 @default.
• W1981805168 hasConceptScore W1981805168C86181022 @default.
• W1981805168 hasConceptScore W1981805168C98274493 @default.
• W1981805168 hasIssue "1-2" @default.
• W1981805168 hasLocation W19818051681 @default.
• W1981805168 hasLocation W19818051682 @default.
• W1981805168 hasOpenAccess W1981805168 @default.
• W1981805168 hasPrimaryLocation W19818051681 @default.

• next