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- W1981814312 abstract "Numbers of serotonin (5-HT) recognition sites of total 5-HT1, 5-HT1A and 5-HT2 subtypes have been measured in frontal, temporal and parietal cortex from human brain postmortem, using binding of [3H] 5-hydroxytryptamine (5-HT), [3H] 8-hydroxy-2-(di-n-propylamino) tetralin and [3H] ketanserin, respectively. A comparison has been made between 11 patients with Alzheimer's disease (AD) and 20 matched controls. Significant disease-related differences were observed only in the parietal cortex for total 5-HT1 and 5-HT2 recognition sites. Age-related decrease in numbers of 5-HT2 recognition sites was seen in the controls, whereas an age-related increase in the numbers of the same site was seen in AD patients. These changes are discussed in relation to disease severity and cortical nerve cell loss in ageing and AD." @default.
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- W1981814312 date "1988-01-01" @default.
- W1981814312 modified "2023-09-24" @default.
- W1981814312 title "Selective loss of serotonin recognition sites in the parietal cortex in Alzheimer's disease" @default.
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- W1981814312 doi "https://doi.org/10.1002/gps.930030106" @default.
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